FOXP1 [The Human Chemical-Genetic Interaction Map Project]

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======= FOXP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXP1
  * **<color #00a2e8>Official Name</color>**: forkhead box P1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27086|27086]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H334|Q9H334]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605515|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-21 secretion|
|interleukin-21 production|
|chemokine secretion|
|chemokine (C-C motif) ligand 2 secretion|
|chemokine (C-X-C motif) ligand 2 production|
|T follicular helper cell differentiation|
|regulation of macrophage colony-stimulating factor production|
|regulation of endothelial tube morphogenesis|
|regulation of interleukin-12 secretion|
|positive regulation of B cell receptor signaling pathway|
|osteoclast development|
|monocyte activation|
|chemokine production|
|endothelial cell activation|
|negative regulation of B cell apoptotic process|
|negative regulation of androgen receptor signaling pathway|
|regulation of B cell apoptotic process|
|regulation of defense response to bacterium|
|regulation of monocyte differentiation|
|positive regulation of antigen receptor-mediated signaling pathway|
|bone cell development|
|regulation of androgen receptor signaling pathway|
|regulation of B cell receptor signaling pathway|
|T-helper cell differentiation|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|negative regulation of lymphocyte apoptotic process|
|alpha-beta T cell differentiation involved in immune response|
|alpha-beta T cell activation involved in immune response|
|T cell differentiation involved in immune response|
|CD4-positive, alpha-beta T cell differentiation|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|CD4-positive, alpha-beta T cell activation|
|osteoclast differentiation|
|androgen receptor binding|
|negative regulation of leukocyte apoptotic process|
|regulation of interleukin-1 beta secretion|
|cytokine secretion|
|alpha-beta T cell differentiation|
|macrophage activation|
|regulation of lymphocyte apoptotic process|
|regulation of interleukin-12 production|
|regulation of interleukin-1 secretion|
|protein self-association|
|myeloid cell development|
|alpha-beta T cell activation|
|regulation of antigen receptor-mediated signaling pathway|
|T cell activation involved in immune response|
|somatic stem cell population maintenance|
|regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of interleukin-1 beta production|
|regulation of leukocyte apoptotic process|
|positive regulation of smooth muscle cell proliferation|
|regulation of interleukin-1 production|
|positive regulation of endothelial cell migration|
|lymphocyte activation involved in immune response|
|myeloid leukocyte differentiation|
|regulation of myeloid leukocyte differentiation|
|regulation of smooth muscle cell proliferation|
|T cell differentiation|
|stem cell population maintenance|
|maintenance of cell number|
|positive regulation of epithelial cell migration|
|regulation of tumor necrosis factor production|
|cytokine production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of endothelial cell migration|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|regulation of morphogenesis of an epithelium|
|bone development|
|regulation of cytokine secretion|
|regulation of epithelial cell migration|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|T cell activation|
|lymphocyte differentiation|
|regulation of leukocyte differentiation|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|leukocyte differentiation|
|regulation of inflammatory response|
|lymphocyte activation|
|sequence-specific DNA binding|
|regulation of hemopoiesis|
|regulation of protein secretion|
|skeletal system development|
|regulation of peptide secretion|
|positive regulation of cell migration|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|hemopoiesis|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|response to bacterium|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|regulation of secretion|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.04|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.71|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.77|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.87|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.95|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.96|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.98|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.18|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11770
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXP1 Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>