FSTL3 [The Human Chemical-Genetic Interaction Map Project]

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======= FSTL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FSTL3
  * **<color #00a2e8>Official Name</color>**: follistatin like 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10272|10272]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95633|O95633]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FSTL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FSTL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605343|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. {ECO:0000269|PubMed:11948405, ECO:0000269|PubMed:15451575, ECO:0000269|PubMed:15574124, ECO:0000269|PubMed:16336961, ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:17878677}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kazal 1|
|FOLN|
|Kazal 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of activin receptor signaling pathway|
|activin binding|
|neuron projection terminus|
|regulation of activin receptor signaling pathway|
|adrenal gland development|
|negative regulation of osteoclast differentiation|
|fibronectin binding|
|negative regulation of myeloid leukocyte differentiation|
|negative regulation of BMP signaling pathway|
|regulation of osteoclast differentiation|
|negative regulation of myeloid cell differentiation|
|secretory granule|
|hematopoietic progenitor cell differentiation|
|regulation of BMP signaling pathway|
|negative regulation of leukocyte differentiation|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of myeloid leukocyte differentiation|
|endocrine system development|
|male gonad development|
|development of primary male sexual characteristics|
|negative regulation of hemopoiesis|
|negative regulation of cellular response to growth factor stimulus|
|male sex differentiation|
|lung development|
|respiratory tube development|
|cellular response to metal ion|
|respiratory system development|
|gonad development|
|development of primary sexual characteristics|
|cellular response to inorganic substance|
|regulation of myeloid cell differentiation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of cell-cell adhesion|
|ossification|
|sex differentiation|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|regulation of leukocyte differentiation|
|renal system development|
|endoplasmic reticulum lumen|
|urogenital system development|
|post-translational protein modification|
|response to metal ion|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|gland development|
|reproductive structure development|
|reproductive system development|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|response to inorganic substance|
|spermatogenesis|
|hemopoiesis|
|male gamete generation|
|hematopoietic or lymphoid organ development|
|immune system development|
|developmental process involved in reproduction|
|regulation of cell adhesion|
|gamete generation|
|negative regulation of cell differentiation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|negative regulation of developmental process|
|Golgi apparatus|
|multi-organism reproductive process|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|extracellular space|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10917
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FSTL3 Expression in NALM6 Cells: 2.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>