FUT8 [The Human Chemical-Genetic Interaction Map Project]

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======= FUT8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FUT8
  * **<color #00a2e8>Official Name</color>**: fucosyltransferase 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2530|2530]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYC5|Q9BYC5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FUT8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FUT8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602589|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. {ECO:0000269|PubMed:17172260, ECO:0000269|PubMed:9133635}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-glycan fucosylation|
|glycoprotein 6-alpha-L-fucosyltransferase activity|
|alpha-(1->6)-fucosyltransferase activity|
|protein glycosylation in Golgi|
|GDP-L-fucose metabolic process|
|L-fucose metabolic process|
|fucose catabolic process|
|L-fucose catabolic process|
|N-glycan processing|
|fucose metabolic process|
|oligosaccharide biosynthetic process|
|fucosylation|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|nucleotide-sugar metabolic process|
|respiratory gaseous exchange by respiratory system|
|oligosaccharide metabolic process|
|hexose catabolic process|
|monosaccharide catabolic process|
|regulation of cellular response to oxidative stress|
|protein N-linked glycosylation|
|regulation of response to oxidative stress|
|Golgi cisterna membrane|
|integrin-mediated signaling pathway|
|transforming growth factor beta receptor signaling pathway|
|receptor metabolic process|
|carbohydrate catabolic process|
|carbohydrate biosynthetic process|
|SH3 domain binding|
|cellular response to transforming growth factor beta stimulus|
|hexose metabolic process|
|response to transforming growth factor beta|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|monosaccharide metabolic process|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|in utero embryonic development|
|glycoprotein metabolic process|
|small molecule catabolic process|
|carbohydrate metabolic process|
|cellular response to growth factor stimulus|
|response to growth factor|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|peptidyl-amino acid modification|
|cell migration|
|embryo development|
|Golgi apparatus|
|carbohydrate derivative metabolic process|
|localization of cell|
|cell motility|
|cellular response to endogenous stimulus|
|locomotion|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|movement of cell or subcellular component|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.75|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14007
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FUT8 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>