FXYD5 [The Human Chemical-Genetic Interaction Map Project]

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======= FXYD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FXYD5
  * **<color #00a2e8>Official Name</color>**: FXYD domain containing ion transport regulator 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=53827|53827]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DB9|Q96DB9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FXYD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FXYD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606669|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. {ECO:0000269|PubMed:11756660}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP1G1 PLM MAT8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of calcium-dependent cell-cell adhesion|
|regulation of calcium-dependent cell-cell adhesion|
|ion channel regulator activity|
|microvillus assembly|
|microvillus organization|
|sodium channel regulator activity|
|regulation of sodium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|regulation of sodium ion transport|
|negative regulation of cell-cell adhesion|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|actin binding|
|negative regulation of cell adhesion|
|regulation of transporter activity|
|cadherin binding|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|regulation of cell-cell adhesion|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|regulation of ion transmembrane transport|
|regulation of transmembrane transport|
|regulation of cell adhesion|
|regulation of ion transport|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|ion transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.04|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.94|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.76|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.73|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.75|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.76|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.77|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.85|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.88|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.28|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.38|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9589
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FXYD5 Expression in NALM6 Cells: 5.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>