FZD6 [The Human Chemical-Genetic Interaction Map Project]

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======= FZD6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FZD6
  * **<color #00a2e8>Official Name</color>**: frizzled class receptor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8323|8323]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60353|O60353]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FZD6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FZD6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603409|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fz|
|Frizzled|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|midbrain morphogenesis|
|embryonic nail plate morphogenesis|
|establishment of body hair or bristle planar orientation|
|establishment of body hair planar orientation|
|cell proliferation in midbrain|
|nail development|
|apicolateral plasma membrane|
|Wnt-activated receptor activity|
|establishment of planar polarity|
|establishment of tissue polarity|
|brain morphogenesis|
|Wnt-protein binding|
|Wnt signaling pathway, calcium modulating pathway|
|morphogenesis of a polarized epithelium|
|embryonic digit morphogenesis|
|hair follicle development|
|skin epidermis development|
|neural precursor cell proliferation|
|molting cycle process|
|hair cycle process|
|amyloid-beta binding|
|midbrain development|
|canonical Wnt signaling pathway|
|neural tube closure|
|tube closure|
|molting cycle|
|hair cycle|
|Wnt signaling pathway, planar cell polarity pathway|
|primary neural tube formation|
|inner ear morphogenesis|
|neural tube formation|
|regulation of establishment of planar polarity|
|ear morphogenesis|
|embryonic epithelial tube formation|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|epithelial tube formation|
|non-canonical Wnt signaling pathway|
|platelet activation|
|cytoplasmic vesicle membrane|
|morphogenesis of embryonic epithelium|
|tube formation|
|appendage morphogenesis|
|limb morphogenesis|
|neural tube development|
|negative regulation of DNA-binding transcription factor activity|
|negative regulation of canonical Wnt signaling pathway|
|limb development|
|appendage development|
|regulation of morphogenesis of an epithelium|
|inner ear development|
|negative regulation of Wnt signaling pathway|
|ear development|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|regulation of canonical Wnt signaling pathway|
|embryonic organ morphogenesis|
|blood coagulation|
|ubiquitin protein ligase binding|
|coagulation|
|hemostasis|
|epithelial tube morphogenesis|
|apical plasma membrane|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|skin development|
|epidermis development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|morphogenesis of an epithelium|
|embryonic organ development|
|wound healing|
|regulation of body fluid levels|
|sensory organ development|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|cell surface|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|G protein-coupled receptor activity|
|brain development|
|head development|
|tube development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|regulation of anatomical structure morphogenesis|
|cell activation|
|epithelium development|
|cell-cell signaling|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|negative regulation of response to stimulus|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.73|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.84|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.91|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.95|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16930
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FZD6 Expression in NALM6 Cells: 3.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>