FZD9 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= FZD9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FZD9
  * **<color #00a2e8>Official Name</color>**: frizzled class receptor 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8326|8326]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00144|O00144]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FZD9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FZD9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601766|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:   Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype.  FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). {ECO:0000250|UniProtKB:Q8K4C8, ECO:0000250|UniProtKB:Q9R216, ECO:0000269|PubMed:27509850}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Frizzled|
|Fz|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of skeletal muscle acetylcholine-gated channel clustering|
|negative regulation of receptor clustering|
|negative regulation of postsynaptic membrane organization|
|negative regulation of neuromuscular junction development|
|bone regeneration|
|regulation of skeletal muscle acetylcholine-gated channel clustering|
|negative regulation of mitochondrial depolarization|
|negative regulation of membrane depolarization|
|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|regulation of neuromuscular junction development|
|regulation of receptor clustering|
|negative regulation of necroptotic process|
|regulation of postsynaptic cytosolic calcium ion concentration|
|negative regulation of programmed necrotic cell death|
|regulation of postsynaptic membrane organization|
|negative regulation of necrotic cell death|
|regulation of necroptotic process|
|Wnt-activated receptor activity|
|filopodium membrane|
|regulation of programmed necrotic cell death|
|regulation of mitochondrial depolarization|
|release of cytochrome c from mitochondria|
|negative regulation of cell cycle arrest|
|negative regulation of synapse organization|
|regulation of necrotic cell death|
|negative regulation of protein localization to membrane|
|neuroblast proliferation|
|Wnt-protein binding|
|positive regulation of bone mineralization|
|regulation of membrane depolarization|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|positive regulation of neural precursor cell proliferation|
|stem cell proliferation|
|negative regulation of mitochondrion organization|
|apoptotic mitochondrial changes|
|tissue regeneration|
|regulation of mitochondrial membrane potential|
|regulation of mitochondrial membrane permeability|
|regulation of bone mineralization|
|neural precursor cell proliferation|
|regulation of membrane permeability|
|postsynapse|
|positive regulation of ossification|
|regulation of neural precursor cell proliferation|
|postsynapse organization|
|canonical Wnt signaling pathway|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|regulation of postsynapse organization|
|mitochondrial membrane|
|regulation of cell cycle arrest|
|B cell differentiation|
|negative regulation of cellular protein localization|
|mitochondrial membrane organization|
|non-canonical Wnt signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|negative regulation of neuron apoptotic process|
|B cell activation|
|regeneration|
|positive regulation of Wnt signaling pathway|
|regulation of mitochondrion organization|
|regulation of protein localization to membrane|
|regulation of ossification|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|mitochondrial transport|
|regulation of synapse organization|
|negative regulation of apoptotic signaling pathway|
|regulation of synapse structure or activity|
|lymphocyte differentiation|
|learning or memory|
|ossification|
|synapse organization|
|regulation of canonical Wnt signaling pathway|
|apoptotic signaling pathway|
|cognition|
|regulation of neuron death|
|negative regulation of cell cycle process|
|regulation of cytosolic calcium ion concentration|
|leukocyte differentiation|
|glutamatergic synapse|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|lymphocyte activation|
|developmental growth|
|growth|
|regulation of apoptotic signaling pathway|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|mitochondrion organization|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|negative regulation of transport|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|regulation of cellular protein localization|
|cell population proliferation|
|cellular metal ion homeostasis|
|hemopoiesis|
|response to wounding|
|behavior|
|negative regulation of cell cycle|
|hematopoietic or lymphoid organ development|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|immune system development|
|positive regulation of programmed cell death|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|regulation of cell cycle process|
|ion homeostasis|
|membrane organization|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|negative regulation of cell death|
|regulation of protein localization|
|programmed cell death|
|cell activation|
|cell death|
|chemical homeostasis|
|cell-cell signaling|
|regulation of cell cycle|
|negative regulation of signal transduction|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.74|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.78|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.87|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.16|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:s1pr4|S1PR4]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3631
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FZD9 Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>