G6PC [The Human Chemical-Genetic Interaction Map Project]

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======= G6PC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: G6PC
  * **<color #00a2e8>Official Name</color>**: glucose-6-phosphatase catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2538|2538]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35575|P35575]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=G6PC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20G6PC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAP2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucose-6-phosphatase activity|
|phosphotransferase activity, alcohol group as acceptor|
|hexose phosphate transport|
|glucose-6-phosphate transport|
|phosphate ion binding|
|urate metabolic process|
|phosphorylated carbohydrate dephosphorylation|
|glycogen catabolic process|
|glucan catabolic process|
|cellular polysaccharide catabolic process|
|response to food|
|polysaccharide catabolic process|
|glucose 6-phosphate metabolic process|
|cellular carbohydrate catabolic process|
|gluconeogenesis|
|hexose biosynthetic process|
|glycogen metabolic process|
|cellular glucan metabolic process|
|glucan metabolic process|
|monosaccharide biosynthetic process|
|energy reserve metabolic process|
|carbohydrate derivative transport|
|triglyceride metabolic process|
|cellular polysaccharide metabolic process|
|cholesterol homeostasis|
|sterol homeostasis|
|multicellular organism growth|
|polysaccharide metabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|integral component of endoplasmic reticulum membrane|
|glucose metabolic process|
|carbohydrate catabolic process|
|organophosphate ester transport|
|carbohydrate biosynthetic process|
|lipid homeostasis|
|hexose metabolic process|
|cellular carbohydrate metabolic process|
|glucose homeostasis|
|carbohydrate homeostasis|
|monosaccharide metabolic process|
|energy derivation by oxidation of organic compounds|
|steroid metabolic process|
|dephosphorylation|
|purine-containing compound metabolic process|
|glycerolipid metabolic process|
|developmental growth|
|growth|
|generation of precursor metabolites and energy|
|organic anion transport|
|carbohydrate metabolic process|
|response to nutrient levels|
|response to extracellular stimulus|
|anion transport|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|chemical homeostasis|
|lipid metabolic process|
|ion transport|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9887
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='G6PC Expression in NALM6 Cells: 1.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>