GAB2 [The Human Chemical-Genetic Interaction Map Project]

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======= GAB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAB2
  * **<color #00a2e8>Official Name</color>**: GRB2 associated binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9846|9846]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQC2|Q9UQC2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606203|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transmembrane receptor protein tyrosine kinase adaptor activity|
|positive regulation of mast cell activation involved in immune response|
|positive regulation of mast cell degranulation|
|positive regulation of mast cell activation|
|positive regulation of leukocyte degranulation|
|phosphatidylinositol-3,4-bisphosphate binding|
|positive regulation of myeloid leukocyte mediated immunity|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|osteoclast differentiation|
|regulation of mast cell activation|
|regulation of leukocyte degranulation|
|positive regulation of regulated secretory pathway|
|regulation of myeloid leukocyte mediated immunity|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|positive regulation of exocytosis|
|myeloid leukocyte differentiation|
|positive regulation of leukocyte mediated immunity|
|regulation of regulated secretory pathway|
|Fc-epsilon receptor signaling pathway|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|positive regulation of immune effector process|
|myeloid cell differentiation|
|regulation of exocytosis|
|Fc receptor signaling pathway|
|axon guidance|
|neuron projection guidance|
|leukocyte differentiation|
|regulation of intracellular transport|
|axonogenesis|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|axon development|
|positive regulation of cell activation|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|regulation of immune effector process|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|neuron projection development|
|cytokine-mediated signaling pathway|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of secretion by cell|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|neuron differentiation|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.73|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|9/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6575
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAB2 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>