GABRB2 [The Human Chemical-Genetic Interaction Map Project]

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======= GABRB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GABRB2
  * **<color #00a2e8>Official Name</color>**: gamma-aminobutyric acid type A receptor subunit beta2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2561|2561]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47870|P47870]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GABRB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GABRB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600232|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO:0000269|PubMed:19763268, ECO:0000269|PubMed:8264558}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan memb|
|Neur chan LBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GABA receptor activity|
|cellular response to histamine|
|inhibitory synapse assembly|
|response to histamine|
|inhibitory extracellular ligand-gated ion channel activity|
|GABA-gated chloride ion channel activity|
|synaptic transmission, GABAergic|
|GABA-A receptor complex|
|GABA-A receptor activity|
|gamma-aminobutyric acid signaling pathway|
|integral component of postsynaptic specialization membrane|
|innervation|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|inner ear receptor cell development|
|extracellular ligand-gated ion channel activity|
|chloride channel complex|
|cochlea development|
|inner ear receptor cell differentiation|
|chloride channel activity|
|mechanoreceptor differentiation|
|GABA-ergic synapse|
|nerve development|
|chloride transmembrane transport|
|synapse assembly|
|regulation of postsynaptic membrane potential|
|chloride transport|
|inorganic anion transmembrane transport|
|cellular response to ammonium ion|
|cytoplasmic vesicle membrane|
|negative regulation of neuron apoptotic process|
|sensory perception of sound|
|inorganic anion transport|
|sensory perception of mechanical stimulus|
|response to ammonium ion|
|inner ear development|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|ear development|
|synapse|
|synapse organization|
|anion transmembrane transport|
|regulation of neuron death|
|neuron projection|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of membrane potential|
|trans-synaptic signaling|
|synaptic signaling|
|cellular response to organic cyclic compound|
|sensory organ development|
|cell junction|
|anion transport|
|cellular response to organonitrogen compound|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|neuron development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|ion transmembrane transport|
|sensory perception|
|negative regulation of cell death|
|response to organonitrogen compound|
|neuron differentiation|
|response to nitrogen compound|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|neurogenesis|
|cell development|
|regulation of cell death|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.85|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.79|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.71|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15592
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GABRB2 Expression in NALM6 Cells: -1.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>