GABRR3 [The Human Chemical-Genetic Interaction Map Project]

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======= GABRR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GABRR3
  * **<color #00a2e8>Official Name</color>**: gamma-aminobutyric acid type A receptor subunit rho3 (gene/pseudogene)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=200959|200959]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A8MPY1|A8MPY1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GABRR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GABRR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618668|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan memb|
|Neur chan LBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GABA-A receptor activity|
|GABA-A receptor complex|
|gamma-aminobutyric acid signaling pathway|
|extracellular ligand-gated ion channel activity|
|chloride channel complex|
|chloride channel activity|
|chloride transmembrane transport|
|chloride transport|
|inorganic anion transmembrane transport|
|inorganic anion transport|
|postsynaptic membrane|
|protein domain specific binding|
|synapse|
|anion transmembrane transport|
|neuron projection|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|cellular component|
|synaptic signaling|
|cell junction|
|anion transport|
|inorganic ion transmembrane transport|
|ion transmembrane transport|
|cell-cell signaling|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11341
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GABRR3 Expression in NALM6 Cells: 0.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>