GATA4 [The Human Chemical-Genetic Interaction Map Project]

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======= GATA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GATA4
  * **<color #00a2e8>Official Name</color>**: GATA binding protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2626|2626]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43694|P43694]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GATA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GATA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600576|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac- specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735). {ECO:0000250|UniProtKB:P46152, ECO:0000250|UniProtKB:Q08369, ECO:0000269|PubMed:15734735, ECO:0000269|PubMed:20081228, ECO:0000269|PubMed:21220346, ECO:0000269|PubMed:24000169, ECO:0000269|PubMed:27984724}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GATA-N|
|GATA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|atrial septum secundum morphogenesis|
|embryonic heart tube anterior/posterior pattern specification|
|cardiac muscle tissue regeneration|
|septum secundum development|
|NFAT protein binding|
|atrial septum primum morphogenesis|
|septum primum development|
|positive regulation of cardioblast differentiation|
|transdifferentiation|
|atrioventricular valve formation|
|regulation of cardioblast differentiation|
|physiological cardiac muscle hypertrophy|
|embryonic foregut morphogenesis|
|physiological muscle hypertrophy|
|cell growth involved in cardiac muscle cell development|
|foregut morphogenesis|
|co-SMAD binding|
|heart valve formation|
|atrial septum morphogenesis|
|response to vitamin A|
|cardiac right ventricle morphogenesis|
|intestinal epithelial cell differentiation|
|positive regulation of stem cell differentiation|
|atrial septum development|
|negative regulation of cardiac muscle cell apoptotic process|
|enhancer sequence-specific DNA binding|
|atrioventricular valve morphogenesis|
|negative regulation of striated muscle cell apoptotic process|
|atrioventricular valve development|
|cardiac muscle tissue growth|
|positive regulation of cardiocyte differentiation|
|positive regulation of vascular endothelial growth factor production|
|heart growth|
|aortic valve morphogenesis|
|cardiac muscle hypertrophy|
|cardiac atrium morphogenesis|
|striated muscle hypertrophy|
|positive regulation of BMP signaling pathway|
|regulation of vascular endothelial growth factor production|
|muscle hypertrophy|
|aortic valve development|
|activating transcription factor binding|
|cardiac atrium development|
|negative regulation of muscle cell apoptotic process|
|semi-lunar valve development|
|regulation of cardiac muscle cell apoptotic process|
|regulation of cardiac muscle cell contraction|
|regulation of striated muscle cell apoptotic process|
|regulation of actin filament-based movement|
|endocardial cushion development|
|negative regulation of cellular response to oxidative stress|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of response to oxidative stress|
|digestive tract morphogenesis|
|regulation of cardiocyte differentiation|
|heart valve morphogenesis|
|cardiac muscle cell development|
|heart looping|
|heart valve development|
|RNA polymerase II transcription factor binding|
|tissue regeneration|
|regulation of oxidative stress-induced cell death|
|cardiac cell development|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|regulation of muscle cell apoptotic process|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|RNA polymerase II transcription factor complex|
|ventricular septum development|
|cellular response to monosaccharide stimulus|
|cardiac ventricle morphogenesis|
|endoderm development|
|cardiac septum morphogenesis|
|regulation of cellular response to oxidative stress|
|regulation of cardiac muscle contraction|
|embryonic heart tube development|
|cellular response to carbohydrate stimulus|
|negative regulation of autophagy|
|regulation of response to oxidative stress|
|response to vitamin|
|regulation of BMP signaling pathway|
|cellular glucose homeostasis|
|developmental cell growth|
|cardiac muscle cell differentiation|
|cell growth|
|regulation of striated muscle contraction|
|columnar/cuboidal epithelial cell differentiation|
|organ growth|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cardiac septum development|
|cardiocyte differentiation|
|determination of left/right symmetry|
|regulation of stem cell differentiation|
|determination of bilateral symmetry|
|specification of symmetry|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|digestive tract development|
|male gonad development|
|development of primary male sexual characteristics|
|striated muscle cell development|
|response to glucose|
|response to hexose|
|digestive system development|
|response to monosaccharide|
|muscle cell development|
|male sex differentiation|
|regeneration|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|positive regulation of angiogenesis|
|cardiac chamber development|
|response to carbohydrate|
|positive regulation of vasculature development|
|glucose homeostasis|
|carbohydrate homeostasis|
|striated muscle cell differentiation|
|gonad development|
|positive regulation of ERK1 and ERK2 cascade|
|response to mechanical stimulus|
|response to nutrient|
|development of primary sexual characteristics|
|anterior/posterior pattern specification|
|transcription regulatory region DNA binding|
|regulation of protein kinase B signaling|
|mesenchyme development|
|negative regulation of apoptotic signaling pathway|
|regulation of muscle system process|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of heart contraction|
|muscle cell differentiation|
|heart morphogenesis|
|negative regulation of cellular catabolic process|
|sex differentiation|
|regulation of cellular response to growth factor stimulus|
|nuclear body|
|transcription coactivator activity|
|striated muscle tissue development|
|regulation of angiogenesis|
|regulation of blood circulation|
|embryonic organ morphogenesis|
|regulation of ERK1 and ERK2 cascade|
|blood coagulation|
|coagulation|
|muscle tissue development|
|hemostasis|
|muscle system process|
|epithelial tube morphogenesis|
|negative regulation of catabolic process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of vasculature development|
|regulation of autophagy|
|transcription factor binding|
|regionalization|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|regulation of apoptotic signaling pathway|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|protein kinase binding|
|muscle structure development|
|wound healing|
|regulation of body fluid levels|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|heart development|
|response to extracellular stimulus|
|positive regulation of MAPK cascade|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|regulation of system process|
|tube morphogenesis|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|regulation of cytokine production|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|regulation of cellular catabolic process|
|zinc ion binding|
|tube development|
|response to lipid|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|negative regulation of cell death|
|regulation of catabolic process|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|DNA binding|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6458
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GATA4 Expression in NALM6 Cells: -3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>