GCDH [The Human Chemical-Genetic Interaction Map Project]

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======= GCDH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GCDH
  * **<color #00a2e8>Official Name</color>**: glutaryl-CoA dehydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2639|2639]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92947|Q92947]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GCDH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GCDH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608801|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive. {ECO:0000269|PubMed:17176108, ECO:0000269|PubMed:6423663, ECO:0000269|PubMed:8541831}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyl-CoA dh N|
|Acyl-CoA dh 1|
|Acyl-CoA dh M|
|Acyl-CoA dh 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutaryl-CoA hydrolase activity|
|glutaryl-CoA dehydrogenase activity|
|fatty acid beta-oxidation using acyl-CoA dehydrogenase|
|lysine catabolic process|
|tryptophan metabolic process|
|lysine metabolic process|
|indolalkylamine metabolic process|
|fatty-acyl-CoA binding|
|aspartate family amino acid catabolic process|
|indole-containing compound metabolic process|
|fatty-acyl-CoA biosynthetic process|
|aromatic amino acid family metabolic process|
|fatty-acyl-CoA metabolic process|
|acyl-CoA biosynthetic process|
|thioester biosynthetic process|
|aspartate family amino acid metabolic process|
|cellular biogenic amine metabolic process|
|fatty acid beta-oxidation|
|flavin adenine dinucleotide binding|
|cellular amine metabolic process|
|purine nucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|ribonucleoside bisphosphate biosynthetic process|
|amine metabolic process|
|fatty acid oxidation|
|lipid oxidation|
|fatty acid derivative biosynthetic process|
|fatty acid catabolic process|
|acyl-CoA metabolic process|
|thioester metabolic process|
|alpha-amino acid catabolic process|
|monocarboxylic acid catabolic process|
|cellular amino acid catabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|fatty acid derivative metabolic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|cellular lipid catabolic process|
|lipid modification|
|alpha-amino acid metabolic process|
|cofactor biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|lipid catabolic process|
|cellular amino acid metabolic process|
|purine ribonucleotide metabolic process|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|small molecule catabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.8|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.19|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.12|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.12|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.96|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.77|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10153
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GCDH Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>