GDF11 [The Human Chemical-Genetic Interaction Map Project]

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======= GDF11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GDF11
  * **<color #00a2e8>Official Name</color>**: growth differentiation factor 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10220|10220]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95390|O95390]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GDF11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GDF11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603936|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634). {ECO:0000250|UniProtKB:Q9Z1W4, ECO:0000269|PubMed:28257634}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGFb propeptide|
|TGF beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spinal cord anterior/posterior patterning|
|spinal cord patterning|
|transforming growth factor beta receptor binding|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|SMAD protein signal transduction|
|regulation of pathway-restricted SMAD protein phosphorylation|
|pancreas development|
|metanephros development|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|roof of mouth development|
|mesonephros development|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|spinal cord development|
|camera-type eye morphogenesis|
|mesoderm development|
|kidney epithelium development|
|eye morphogenesis|
|cell maturation|
|growth factor activity|
|cytokine activity|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|anterior/posterior pattern specification|
|negative regulation of neuron differentiation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|developmental maturation|
|sensory organ morphogenesis|
|kidney development|
|renal system development|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|camera-type eye development|
|urogenital system development|
|regionalization|
|negative regulation of cell development|
|eye development|
|visual system development|
|sensory system development|
|pattern specification process|
|skeletal system development|
|sensory organ development|
|protein-containing complex|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of neurogenesis|
|tube development|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|central nervous system development|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11728
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GDF11 Expression in NALM6 Cells: 7.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>