GDF9 [The Human Chemical-Genetic Interaction Map Project]

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======= GDF9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GDF9
  * **<color #00a2e8>Official Name</color>**: growth differentiation factor 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2661|2661]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60383|O60383]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GDF9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GDF9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601918|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. {ECO:0000269|PubMed:12050262, ECO:0000269|PubMed:19366876, ECO:0000269|PubMed:20660033, ECO:0000269|PubMed:21632818, ECO:0000269|PubMed:21829661}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGF beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of progesterone secretion|
|oocyte growth|
|regulation of female gonad development|
|regulation of steroid hormone secretion|
|regulation of gonad development|
|oocyte development|
|transforming growth factor beta receptor binding|
|oocyte differentiation|
|regulation of endocrine process|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|SMAD protein signal transduction|
|regulation of pathway-restricted SMAD protein phosphorylation|
|oogenesis|
|developmental cell growth|
|cell growth|
|BMP signaling pathway|
|regulation of response to drug|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|response to BMP|
|cellular response to BMP stimulus|
|regulation of lipid transport|
|female gamete generation|
|regulation of lipid localization|
|cellular response to transforming growth factor beta stimulus|
|regulation of reproductive process|
|response to transforming growth factor beta|
|growth factor activity|
|cytokine activity|
|negative regulation of cell growth|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of growth|
|germ cell development|
|regulation of hormone secretion|
|cellular process involved in reproduction in multicellular organism|
|developmental growth|
|growth|
|regulation of cell growth|
|cellular response to growth factor stimulus|
|response to growth factor|
|regulation of hormone levels|
|regulation of system process|
|developmental process involved in reproduction|
|regulation of growth|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|positive regulation of cell population proliferation|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.14|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.09|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.89|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.74|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.78|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.91|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.99|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17673
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GDF9 Expression in NALM6 Cells: 1.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>