GDI1 [The Human Chemical-Genetic Interaction Map Project]

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======= GDI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GDI1
  * **<color #00a2e8>Official Name</color>**: GDP dissociation inhibitor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2664|2664]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31150|P31150]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GDI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GDI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300104|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269|PubMed:23815289}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GDI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rab GDP-dissociation inhibitor activity|
|negative regulation of protein targeting to membrane|
|GDP-dissociation inhibitor activity|
|negative regulation of protein localization to membrane|
|myelin sheath|
|regulation of protein targeting to membrane|
|negative regulation of intracellular protein transport|
|positive regulation of axon extension|
|negative regulation of intracellular transport|
|negative regulation of axonogenesis|
|Rab protein signal transduction|
|regulation of protein targeting|
|positive regulation of axonogenesis|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of extent of cell growth|
|negative regulation of cellular protein localization|
|Rab GTPase binding|
|response to calcium ion|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|midbody|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|negative regulation of protein transport|
|regulation of cell size|
|negative regulation of cell projection organization|
|regulation of axonogenesis|
|negative regulation of establishment of protein localization|
|regulation of protein localization to membrane|
|negative regulation of neuron differentiation|
|regulation of intracellular protein transport|
|Ras protein signal transduction|
|positive regulation of growth|
|positive regulation of neuron projection development|
|GTPase activator activity|
|negative regulation of neurogenesis|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|small GTPase mediated signal transduction|
|regulation of developmental growth|
|negative regulation of cell development|
|regulation of small GTPase mediated signal transduction|
|regulation of intracellular transport|
|positive regulation of neuron differentiation|
|response to metal ion|
|neuronal cell body|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|positive regulation of GTPase activity|
|regulation of cell growth|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|response to inorganic substance|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|protein-containing complex|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|regulation of neurogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|Golgi apparatus|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|protein transport|
|generation of neurons|
|peptide transport|
|amide transport|
|establishment of protein localization|
|neurogenesis|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17556
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GDI1 Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>