GGT7 [The Human Chemical-Genetic Interaction Map Project]

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======= GGT7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GGT7
  * **<color #00a2e8>Official Name</color>**: gamma-glutamyltransferase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2686|2686]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJ14|Q9UJ14]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GGT7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GGT7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612342|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves glutathione conjugates. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G glu transpept|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyltransferase activity|
|hypoglycin A gamma-glutamyl transpeptidase activity|
|leukotriene C4 gamma-glutamyl transferase activity|
|glutathione hydrolase activity|
|leukotriene D4 metabolic process|
|glutathione catabolic process|
|leukotriene D4 biosynthetic process|
|glutathione biosynthetic process|
|nonribosomal peptide biosynthetic process|
|leukotriene biosynthetic process|
|cellular modified amino acid catabolic process|
|peptide catabolic process|
|leukotriene metabolic process|
|icosanoid biosynthetic process|
|cellular modified amino acid biosynthetic process|
|negative regulation of response to oxidative stress|
|glutathione metabolic process|
|sulfur compound catabolic process|
|cofactor catabolic process|
|regulation of response to oxidative stress|
|fatty acid derivative biosynthetic process|
|icosanoid metabolic process|
|fatty acid derivative metabolic process|
|sulfur compound biosynthetic process|
|cellular modified amino acid metabolic process|
|cofactor biosynthetic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|sulfur compound metabolic process|
|translation|
|peptide biosynthetic process|
|cofactor metabolic process|
|drug metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|small molecule biosynthetic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.78|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2.07|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.524|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5515
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GGT7 Expression in NALM6 Cells: 2.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>