GHRH [The Human Chemical-Genetic Interaction Map Project]

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======= GHRH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GHRH
  * **<color #00a2e8>Official Name</color>**: growth hormone releasing hormone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2691|2691]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01286|P01286]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GHRH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GHRH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of circadian sleep/wake cycle, REM sleep|
|growth hormone-releasing hormone receptor binding|
|growth hormone-releasing hormone activity|
|regulation of circadian sleep/wake cycle, REM sleep|
|positive regulation of circadian sleep/wake cycle, sleep|
|growth hormone secretion|
|positive regulation of growth hormone secretion|
|peptide hormone receptor binding|
|regulation of growth hormone secretion|
|positive regulation of insulin-like growth factor receptor signaling pathway|
|adenohypophysis development|
|positive regulation of circadian rhythm|
|regulation of circadian sleep/wake cycle, sleep|
|regulation of circadian sleep/wake cycle|
|response to food|
|regulation of insulin-like growth factor receptor signaling pathway|
|neuropeptide hormone activity|
|positive regulation of behavior|
|positive regulation of multicellular organism growth|
|pituitary gland development|
|terminal bouton|
|peptide hormone secretion|
|regulation of multicellular organism growth|
|regulation of behavior|
|hormone secretion|
|diencephalon development|
|hormone transport|
|positive regulation of peptide hormone secretion|
|regulation of circadian rhythm|
|endocrine system development|
|positive regulation of hormone secretion|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|perikaryon|
|cAMP-mediated signaling|
|signal release|
|positive regulation of developmental growth|
|cyclic-nucleotide-mediated signaling|
|peptide secretion|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of growth|
|regulation of hormone secretion|
|positive regulation of peptide secretion|
|neuron projection|
|regulation of developmental growth|
|second-messenger-mediated signaling|
|forebrain development|
|positive regulation of secretion by cell|
|gland development|
|positive regulation of secretion|
|regulation of peptide secretion|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|regulation of growth|
|regulation of peptide transport|
|brain development|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|positive regulation of cell population proliferation|
|central nervous system development|
|positive regulation of transport|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|peptide transport|
|amide transport|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.72|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3235
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GHRH Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>