GINS2 [The Human Chemical-Genetic Interaction Map Project]

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======= GINS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GINS2
  * **<color #00a2e8>Official Name</color>**: GINS complex subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51659|51659]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y248|Q9Y248]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GINS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GINS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610609|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. {ECO:0000269|PubMed:17417653}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sld5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GINS complex|
|replication fork protection complex|
|double-strand break repair via break-induced replication|
|DNA strand elongation involved in DNA replication|
|3-5 DNA helicase activity|
|DNA strand elongation|
|double-strand break repair via homologous recombination|
|recombinational repair|
|DNA duplex unwinding|
|DNA geometric change|
|DNA-dependent DNA replication|
|double-strand break repair|
|DNA replication|
|DNA recombination|
|DNA conformation change|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|chromosome organization|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.22|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.81|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.76|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.75|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.71|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 737/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 45
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GINS2 Expression in NALM6 Cells: 5.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>