GJA10 [The Human Chemical-Genetic Interaction Map Project]

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======= GJA10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GJA10
  * **<color #00a2e8>Official Name</color>**: gap junction protein alpha 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84694|84694]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969M2|Q969M2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GJA10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GJA10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611924|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Connexin CCC|
|Connexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gap junction channel activity|
|detection of light stimulus involved in sensory perception|
|detection of light stimulus involved in visual perception|
|connexin complex|
|detection of visible light|
|detection of light stimulus|
|synapse assembly|
|detection of external stimulus|
|detection of abiotic stimulus|
|visual perception|
|sensory perception of light stimulus|
|synapse organization|
|response to light stimulus|
|response to radiation|
|detection of stimulus involved in sensory perception|
|detection of stimulus|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|sensory perception|
|multi-organism reproductive process|
|response to abiotic stimulus|
|transmembrane transport|
|nervous system process|
|reproductive process|
|reproduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.71|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.8|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.83|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.88|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.96|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.96|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.15|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3160
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GJA10 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>