GLRA1 [The Human Chemical-Genetic Interaction Map Project]

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======= GLRA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLRA1
  * **<color #00a2e8>Official Name</color>**: glycine receptor alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2741|2741]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23415|P23415]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLRA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLRA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138491|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). {ECO:0000250|UniProtKB:Q64018, ECO:0000269|PubMed:14551753, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:22715885, ECO:0000269|PubMed:22973015, ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:25730860, ECO:0000269|PubMed:25973519, ECO:0000269|PubMed:7920629, ECO:0000269|PubMed:7925268, ECO:0000269|PubMed:9009272, ECO:0000305|PubMed:8298642}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan LBD|
|Neur chan memb|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|taurine binding|
|extracellularly glycine-gated chloride channel activity|
|negative regulation of transmission of nerve impulse|
|glycinergic synapse|
|synaptic transmission, glycinergic|
|righting reflex|
|inhibitory postsynaptic potential|
|positive regulation of acrosome reaction|
|regulation of respiratory gaseous exchange by nervous system process|
|positive regulation of fertilization|
|cellular response to ethanol|
|inhibitory synapse|
|glycine binding|
|regulation of respiratory system process|
|neuromuscular process controlling posture|
|regulation of transmission of nerve impulse|
|regulation of acrosome reaction|
|reflex|
|acrosome reaction|
|regulation of respiratory gaseous exchange|
|cellular response to zinc ion|
|calyx of Held|
|negative regulation of nervous system process|
|integral component of postsynaptic specialization membrane|
|startle response|
|regulation of fertilization|
|adult walking behavior|
|walking behavior|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|extracellular ligand-gated ion channel activity|
|chloride channel complex|
|response to zinc ion|
|chloride channel activity|
|integral component of presynaptic membrane|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|cellular response to amino acid stimulus|
|adult locomotory behavior|
|positive regulation of reproductive process|
|cellular response to alcohol|
|chloride transmembrane transport|
|action potential|
|regulation of postsynaptic membrane potential|
|chloride transport|
|neuropeptide signaling pathway|
|protein heterooligomerization|
|neuromuscular process|
|inorganic anion transmembrane transport|
|response to amino acid|
|cellular response to antibiotic|
|response to ethanol|
|perikaryon|
|regulation of nervous system process|
|transmembrane signaling receptor activity|
|single fertilization|
|adult behavior|
|inorganic anion transport|
|regulation of reproductive process|
|fertilization|
|cellular response to metal ion|
|locomotory behavior|
|postsynaptic membrane|
|cellular response to acid chemical|
|cellular response to toxic substance|
|cellular response to inorganic substance|
|visual perception|
|sensory perception of light stimulus|
|response to alcohol|
|muscle contraction|
|synapse|
|anion transmembrane transport|
|muscle system process|
|response to antibiotic|
|neuron projection|
|protein homooligomerization|
|response to acid chemical|
|response to metal ion|
|neuronal cell body|
|external side of plasma membrane|
|cellular response to drug|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|dendrite|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|synaptic signaling|
|response to toxic substance|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|response to inorganic substance|
|cell junction|
|behavior|
|anion transport|
|regulation of system process|
|cellular response to organonitrogen compound|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|intracellular membrane-bounded organelle|
|regulation of multi-organism process|
|sexual reproduction|
|zinc ion binding|
|ion transmembrane transport|
|sensory perception|
|multi-organism reproductive process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13883
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLRA1 Expression in NALM6 Cells: 0.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>