GLRA3 [The Human Chemical-Genetic Interaction Map Project]

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======= GLRA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLRA3
  * **<color #00a2e8>Official Name</color>**: glycine receptor alpha 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8001|8001]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75311|O75311]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLRA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLRA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600421|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity). {ECO:0000250|UniProtKB:P24524, ECO:0000250|UniProtKB:Q91XP5, ECO:0000269|PubMed:26416729, ECO:0000269|PubMed:9677400}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan memb|
|Neur chan LBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycine-gated chloride ion channel activity|
|glycine-gated chloride channel complex|
|extracellularly glycine-gated chloride channel activity|
|synaptic transmission, glycinergic|
|glycine binding|
|extracellular ligand-gated ion channel activity|
|chloride channel activity|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|chloride transmembrane transport|
|regulation of postsynaptic membrane potential|
|chloride transport|
|neuropeptide signaling pathway|
|inorganic anion transmembrane transport|
|response to amino acid|
|perikaryon|
|transmembrane signaling receptor activity|
|inorganic anion transport|
|postsynaptic membrane|
|synapse|
|anion transmembrane transport|
|neuron projection|
|protein homooligomerization|
|response to acid chemical|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|synaptic signaling|
|protein complex oligomerization|
|cell junction|
|anion transport|
|inorganic ion transmembrane transport|
|ion transmembrane transport|
|response to organonitrogen compound|
|response to nitrogen compound|
|cell-cell signaling|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|1.72|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14633
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLRA3 Expression in NALM6 Cells: 1.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>