GLRX [The Human Chemical-Genetic Interaction Map Project]

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======= GLRX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLRX
  * **<color #00a2e8>Official Name</color>**: glutaredoxin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2745|2745]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35754|P35754]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLRX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLRX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600443|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glutaredoxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein deglutathionylation|
|glutathione oxidoreductase activity|
|glutathione disulfide oxidoreductase activity|
|positive regulation of membrane potential|
|positive regulation of sodium ion transmembrane transporter activity|
|positive regulation of sodium ion transmembrane transport|
|nucleobase-containing small molecule interconversion|
|positive regulation of sodium ion transport|
|regulation of sodium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|cell redox homeostasis|
|electron transfer activity|
|regulation of sodium ion transport|
|positive regulation of ion transmembrane transporter activity|
|protein N-terminus binding|
|positive regulation of transporter activity|
|positive regulation of cation transmembrane transport|
|positive regulation of ion transmembrane transport|
|electron transport chain|
|positive regulation of transmembrane transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|generation of precursor metabolites and energy|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|nucleobase-containing small molecule metabolic process|
|regulation of transmembrane transport|
|regulation of ion transport|
|cellular homeostasis|
|oxidation-reduction process|
|positive regulation of transport|
|homeostatic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13549
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLRX Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>