GNA12 [The Human Chemical-Genetic Interaction Map Project]

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======= GNA12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNA12
  * **<color #00a2e8>Official Name</color>**: G protein subunit alpha 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2768|2768]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q03113|Q03113]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNA12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNA12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604394|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|G-alpha|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|D5 dopamine receptor binding|
|G-protein beta/gamma-subunit complex binding|
|regulation of fibroblast migration|
|heterotrimeric G-protein complex|
|brush border membrane|
|lateral plasma membrane|
|embryonic digit morphogenesis|
|G protein-coupled receptor binding|
|Rho protein signal transduction|
|regulation of TOR signaling|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|platelet activation|
|limb morphogenesis|
|appendage morphogenesis|
|regulation of cell shape|
|regulation of ubiquitin-dependent protein catabolic process|
|limb development|
|appendage development|
|regulation of proteasomal protein catabolic process|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of proteolysis involved in cellular protein catabolic process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|Ras protein signal transduction|
|regulation of cellular protein catabolic process|
|blood coagulation|
|coagulation|
|hemostasis|
|small GTPase mediated signal transduction|
|GTPase activity|
|in utero embryonic development|
|regulation of protein catabolic process|
|GTP binding|
|focal adhesion|
|wound healing|
|regulation of cell morphogenesis|
|regulation of body fluid levels|
|embryonic morphogenesis|
|response to wounding|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of proteolysis|
|regulation of cellular catabolic process|
|regulation of cell migration|
|regulation of cell motility|
|embryo development|
|regulation of locomotion|
|regulation of catabolic process|
|regulation of cellular component movement|
|response to drug|
|regulation of anatomical structure morphogenesis|
|cell activation|
|G protein-coupled receptor signaling pathway|
|intracellular signal transduction|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.74|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.87|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.38|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.19|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.32|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|3.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6247
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNA12 Expression in NALM6 Cells: 5.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>