GNAQ [The Human Chemical-Genetic Interaction Map Project]

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======= GNAQ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNAQ
  * **<color #00a2e8>Official Name</color>**: G protein subunit alpha q
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2776|2776]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50148|P50148]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNAQ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNAQ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600998|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-alpha|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type 2A serotonin receptor binding|
|phototransduction, visible light|
|G protein-coupled acetylcholine receptor signaling pathway|
|G-protein beta/gamma-subunit complex binding|
|entrainment of circadian clock|
|acetylcholine receptor signaling pathway|
|heterotrimeric G-protein complex|
|activation of phospholipase C activity|
|response to acetylcholine|
|cellular response to acetylcholine|
|postsynaptic signal transduction|
|positive regulation of phospholipase C activity|
|phototransduction|
|glutamate receptor signaling pathway|
|regulation of phospholipase C activity|
|detection of visible light|
|positive regulation of phospholipase activity|
|detection of light stimulus|
|photoreceptor outer segment|
|G protein-coupled receptor binding|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|signal transduction involved in cellular response to ammonium ion|
|action potential|
|regulation of lipase activity|
|regulation of circadian rhythm|
|detection of external stimulus|
|detection of abiotic stimulus|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cellular response to ammonium ion|
|platelet activation|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|protein stabilization|
|response to ammonium ion|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|negative regulation of protein kinase activity|
|nuclear membrane|
|negative regulation of kinase activity|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|negative regulation of transferase activity|
|regulation of canonical Wnt signaling pathway|
|GTPase activator activity|
|regulation of protein stability|
|blood coagulation|
|coagulation|
|hemostasis|
|lysosomal membrane|
|response to light stimulus|
|GTPase activity|
|second-messenger-mediated signaling|
|regulation of Wnt signaling pathway|
|GTP binding|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|regulation of membrane potential|
|response to radiation|
|negative regulation of phosphorylation|
|synaptic signaling|
|wound healing|
|regulation of GTPase activity|
|regulation of body fluid levels|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|response to wounding|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|detection of stimulus|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|response to hormone|
|regulation of transferase activity|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10336
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNAQ Expression in NALM6 Cells: 0.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>