GNB3 [The Human Chemical-Genetic Interaction Map Project]

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======= GNB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNB3
  * **<color #00a2e8>Official Name</color>**: G protein subunit beta 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2784|2784]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16520|P16520]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of locomotion involved in locomotory behavior|
|cell volume homeostasis|
|spectrin binding|
|regulation of feeding behavior|
|GTPase binding|
|regulation of triglyceride metabolic process|
|regulation of hormone metabolic process|
|regulation of cholesterol metabolic process|
|cell body|
|regulation of behavior|
|regulation of phospholipid metabolic process|
|regulation of glucose metabolic process|
|regulation of steroid metabolic process|
|regulation of fat cell differentiation|
|regulation of cellular carbohydrate metabolic process|
|regulation of cell size|
|regulation of blood pressure|
|regulation of carbohydrate metabolic process|
|protein folding|
|GTPase activity|
|regulation of cellular component size|
|blood circulation|
|regulation of lipid metabolic process|
|circulatory system process|
|dendrite|
|regulation of small molecule metabolic process|
|regulation of anatomical structure size|
|regulation of hormone levels|
|cellular homeostasis|
|regulation of locomotion|
|G protein-coupled receptor signaling pathway|
|homeostatic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.466|
|[[:human genes:a:akirin2|AKIRIN2]]|0.428|
|[[:human genes:c:ccdc94|CCDC94]]|0.423|
|[[:human genes:s:sf3a3|SF3A3]]|0.411|
|[[:human genes:c:chd4|CHD4]]|0.408|
|[[:human genes:o:orc1|ORC1]]|0.408|
|[[:human genes:i:ints5|INTS5]]|0.405|
|[[:human genes:s:slc4a1|SLC4A1]]|0.404|
|[[:human genes:p:psmd1|PSMD1]]|0.404|
|[[:human genes:z:znf106|ZNF106]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2355
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNB3 Expression in NALM6 Cells: 2.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>