GNL3 [The Human Chemical-Genetic Interaction Map Project]

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======= GNL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNL3
  * **<color #00a2e8>Official Name</color>**: G protein nucleolar 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26354|26354]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVP2|Q9BVP2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608011|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12464630, ECO:0000269|PubMed:16012751}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MMR HSR1|
|GN3L Grn1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein sumoylation|
|positive regulation of protein localization to chromosome, telomeric region|
|regulation of protein localization to chromosome, telomeric region|
|regulation of protein sumoylation|
|mRNA 5-UTR binding|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|stem cell division|
|regulation of pri-miRNA transcription by RNA polymerase II|
|positive regulation of telomere maintenance|
|regulation of telomere maintenance|
|positive regulation of protein modification by small protein conjugation or removal|
|stem cell population maintenance|
|maintenance of cell number|
|positive regulation of chromosome organization|
|positive regulation of DNA metabolic process|
|regulation of protein modification by small protein conjugation or removal|
|nuclear body|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|GTP binding|
|cell division|
|regulation of cellular protein localization|
|cell population proliferation|
|positive regulation of organelle organization|
|nucleolus|
|regulation of cellular localization|
|regulation of protein localization|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of organelle organization|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.47|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.34|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.99|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.92|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.85|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.7|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.75|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.86|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 108/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|4/28|
|bone|0/26|
|breast|6/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|5/21|
|liver|1/20|
|lung|14/75|
|lymphocyte|3/16|
|ovary|3/26|
|pancreas|2/24|
|peripheral nervous system|5/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|9/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1529
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNL3 Expression in NALM6 Cells: 7.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>