GNPNAT1 [The Human Chemical-Genetic Interaction Map Project]

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======= GNPNAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNPNAT1
  * **<color #00a2e8>Official Name</color>**: glucosamine-phosphate N-acetyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64841|64841]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EK6|Q96EK6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNPNAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNPNAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616510|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acetyltransf 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucosamine 6-phosphate N-acetyltransferase activity|
|glucosamine metabolic process|
|UDP-N-acetylglucosamine biosynthetic process|
|amino sugar biosynthetic process|
|monosaccharide binding|
|UDP-N-acetylglucosamine metabolic process|
|N-acetylglucosamine metabolic process|
|nucleotide-sugar biosynthetic process|
|glucosamine-containing compound metabolic process|
|nucleotide-sugar metabolic process|
|amino sugar metabolic process|
|endoplasmic reticulum-Golgi intermediate compartment|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|liver development|
|late endosome|
|hepaticobiliary system development|
|endosome membrane|
|gland development|
|nucleobase-containing small molecule metabolic process|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|Golgi apparatus|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.35|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.7|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.74|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.77|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.82|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.83|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.87|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmvk|PMVK]]|0.476|
|[[:human genes:p:pgm3|PGM3]]|0.436|
|[[:human genes:m:mettl1|METTL1]]|0.422|
|[[:human genes:t:trmt61a|TRMT61A]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1239
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNPNAT1 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>