GPM6B [The Human Chemical-Genetic Interaction Map Project]

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======= GPM6B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPM6B
  * **<color #00a2e8>Official Name</color>**: glycoprotein M6B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2824|2824]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13491|Q13491]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPM6B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPM6B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300051|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions such as membrane trafficking and cell-to-cell communication. This protein may also be involved in osteoblast differentiation. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes Y and 22. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. {ECO:0000269|PubMed:21638316}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myelin PLP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of serotonin uptake|
|regulation of serotonin uptake|
|negative regulation of neurotransmitter uptake|
|negative regulation of protein localization to cell surface|
|regulation of neurotransmitter uptake|
|extracellular matrix assembly|
|negative regulation of neurotransmitter transport|
|regulation of protein localization to cell surface|
|positive regulation of bone mineralization|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|regulation of adherens junction organization|
|regulation of bone mineralization|
|positive regulation of ossification|
|regulation of cell junction assembly|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|negative regulation of cellular protein localization|
|regulation of cell-matrix adhesion|
|regulation of neurotransmitter transport|
|negative regulation of ion transport|
|regulation of ossification|
|regulation of cell-substrate adhesion|
|membrane raft|
|ossification|
|extracellular matrix organization|
|regulation of actin cytoskeleton organization|
|regulation of neurotransmitter levels|
|extracellular structure organization|
|regulation of actin filament-based process|
|negative regulation of transport|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|neuron projection development|
|regulation of cell adhesion|
|regulation of ion transport|
|molecular function|
|neuron development|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|neuron differentiation|
|regulation of protein localization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|protein transport|
|generation of neurons|
|peptide transport|
|amide transport|
|establishment of protein localization|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.79|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7913
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPM6B Expression in NALM6 Cells: 5.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>