GPR33 [The Human Chemical-Genetic Interaction Map Project]

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======= GPR33 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR33
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 33 (gene/pseudogene)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2856|2856]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q49SQ1|Q49SQ1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR33&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR33|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610118|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Orphan receptor; could be a chemoattractant receptor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|complement receptor mediated signaling pathway|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|cellular calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|immune response-regulating cell surface receptor signaling pathway|
|divalent inorganic cation homeostasis|
|inflammatory response|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|ion homeostasis|
|positive regulation of immune response|
|cellular homeostasis|
|chemical homeostasis|
|positive regulation of immune system process|
|regulation of immune response|
|G protein-coupled receptor signaling pathway|
|defense response|
|homeostatic process|
|regulation of immune system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.05|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.98|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.86|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.85|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.84|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.83|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.81|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.72|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.7|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.71|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.84|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.86|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.88|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.9|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.43|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8848
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR33 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>