GPR55 [The Human Chemical-Genetic Interaction Map Project]

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======= GPR55 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR55
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 55
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9290|9290]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2T6|Q9Y2T6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR55&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR55|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604107|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. {ECO:0000250, ECO:0000269|PubMed:19805329}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cannabinoid receptor activity|
|cannabinoid signaling pathway|
|bone resorption|
|negative regulation of osteoclast differentiation|
|positive regulation of Rho protein signal transduction|
|activation of phospholipase C activity|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|positive regulation of phospholipase C activity|
|negative regulation of myeloid leukocyte differentiation|
|regulation of phospholipase C activity|
|bone remodeling|
|positive regulation of phospholipase activity|
|positive regulation of Ras protein signal transduction|
|regulation of osteoclast differentiation|
|positive regulation of small GTPase mediated signal transduction|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|negative regulation of myeloid cell differentiation|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of lipase activity|
|negative regulation of leukocyte differentiation|
|tissue remodeling|
|regulation of myeloid leukocyte differentiation|
|negative regulation of hemopoiesis|
|regulation of Rho protein signal transduction|
|tissue homeostasis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of myeloid cell differentiation|
|regulation of Ras protein signal transduction|
|regulation of leukocyte differentiation|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|anatomical structure homeostasis|
|regulation of small GTPase mediated signal transduction|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|calcium ion homeostasis|
|regulation of hemopoiesis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cellular homeostasis|
|negative regulation of developmental process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.74|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.9|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.97|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5287
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR55 Expression in NALM6 Cells: 1.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>