GPR75-ASB3 [The Human Chemical-Genetic Interaction Map Project]

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======= GPR75-ASB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/A
  * **<color #00a2e8>Official Name</color>**: N/A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: N/A
  * **<color #00a2e8>UniProt</color>**: N/A
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR75-ASB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR75-ASB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. {ECO:0000269|PubMed:15899873}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|SOCS box|
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.51|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.37|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.29|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.28|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.23|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.22|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-2.17|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.16|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.16|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.15|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.01|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.99|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.98|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.97|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.95|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.9|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.87|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.81|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.78|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.73|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.72|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8658
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR75-ASB3 Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>