GPRC5A [The Human Chemical-Genetic Interaction Map Project]

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======= GPRC5A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPRC5A
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor class C group 5 member A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9052|9052]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFJ5|Q8NFJ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPRC5A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPRC5A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604138|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). {ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of epidermal growth factor-activated receptor activity|
|protein kinase activator activity|
|regulation of epidermal growth factor-activated receptor activity|
|negative regulation of protein tyrosine kinase activity|
|negative regulation of epidermal growth factor receptor signaling pathway|
|negative regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of ERBB signaling pathway|
|negative regulation of signaling receptor activity|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|vesicle|
|cytoplasmic vesicle membrane|
|regulation of signaling receptor activity|
|receptor complex|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of transferase activity|
|cadherin binding|
|activation of protein kinase activity|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|positive regulation of protein kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|positive regulation of transferase activity|
|intracellular membrane-bounded organelle|
|G protein-coupled receptor activity|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|nucleolus|
|regulation of kinase activity|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-2.25|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.92|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.83|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11448
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPRC5A Expression in NALM6 Cells: 2.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>