GPS2 [The Human Chemical-Genetic Interaction Map Project]

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======= GPS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPS2
  * **<color #00a2e8>Official Name</color>**: G protein pathway suppressor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2874|2874]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13227|Q13227]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601935|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). May act as a regulator of adipogenisis (By similarity). {ECO:0000250|UniProtKB:Q921N8, ECO:0000269|PubMed:8943324}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein K63-linked ubiquitination|
|negative regulation of B cell receptor signaling pathway|
|negative regulation of protein polyubiquitination|
|positive regulation of peroxisome proliferator activated receptor signaling pathway|
|regulation of protein K63-linked ubiquitination|
|GTPase inhibitor activity|
|regulation of peroxisome proliferator activated receptor signaling pathway|
|positive regulation of cholesterol efflux|
|response to mitochondrial depolarisation|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|regulation of protein polyubiquitination|
|positive regulation of cholesterol transport|
|regulation of cholesterol efflux|
|positive regulation of sterol transport|
|regulation of B cell receptor signaling pathway|
|negative regulation of antigen receptor-mediated signaling pathway|
|inactivation of MAPK activity|
|cyclin binding|
|negative regulation of JNK cascade|
|negative regulation of toll-like receptor signaling pathway|
|regulation of cholesterol transport|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of fat cell differentiation|
|regulation of sterol transport|
|negative regulation of GTPase activity|
|transcriptional repressor complex|
|regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of cytokine-mediated signaling pathway|
|positive regulation of lipid transport|
|regulation of antigen receptor-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|regulation of toll-like receptor signaling pathway|
|negative regulation of protein ubiquitination|
|negative regulation of MAP kinase activity|
|JNK cascade|
|positive regulation of lipid localization|
|negative regulation of protein modification by small protein conjugation or removal|
|stress-activated MAPK cascade|
|B cell differentiation|
|regulation of lipid transport|
|regulation of fat cell differentiation|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of inflammatory response|
|regulation of lipid localization|
|stress-activated protein kinase signaling cascade|
|B cell activation|
|regulation of cytokine-mediated signaling pathway|
|negative regulation of MAPK cascade|
|regulation of response to cytokine stimulus|
|regulation of JNK cascade|
|regulation of protein ubiquitination|
|negative regulation of defense response|
|negative regulation of protein kinase activity|
|regulation of protein modification by small protein conjugation or removal|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|lymphocyte differentiation|
|transcription corepressor activity|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|transcription coactivator activity|
|leukocyte differentiation|
|regulation of inflammatory response|
|regulation of MAP kinase activity|
|negative regulation of response to external stimulus|
|MAPK cascade|
|lymphocyte activation|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|negative regulation of protein phosphorylation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|regulation of GTPase activity|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|immune system development|
|viral process|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|leukocyte activation|
|negative regulation of developmental process|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of transport|
|negative regulation of cellular protein metabolic process|
|cell activation|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.34|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.29|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.14|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.03|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-2.02|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.98|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.93|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.72|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.72|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.72|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.86|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.95|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.25|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.26|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.69|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tsc1|TSC1]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10574
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPS2 Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>