GPSM1 [The Human Chemical-Genetic Interaction Map Project]

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======= GPSM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPSM1
  * **<color #00a2e8>Official Name</color>**: G protein signaling modulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26086|26086]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YR5|Q86YR5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPSM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPSM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609491|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GoLoco|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of guanyl-nucleotide exchange factor activity|
|regulation of guanyl-nucleotide exchange factor activity|
|GDP-dissociation inhibitor activity|
|regulation of GTP binding|
|negative regulation of GTPase activity|
|positive regulation of macroautophagy|
|negative regulation of protein binding|
|positive regulation of autophagy|
|cell cortex|
|negative regulation of binding|
|regulation of macroautophagy|
|positive regulation of binding|
|regulation of protein binding|
|regulation of autophagy|
|positive regulation of cellular catabolic process|
|regulation of binding|
|positive regulation of catabolic process|
|negative regulation of hydrolase activity|
|regulation of GTPase activity|
|protein-containing complex|
|Golgi membrane|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|endoplasmic reticulum membrane|
|regulation of catabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.77|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5155
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPSM1 Expression in NALM6 Cells: 5.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>