GPSM3 [The Human Chemical-Genetic Interaction Map Project]

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======= GPSM3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPSM3
  * **<color #00a2e8>Official Name</color>**: G protein signaling modulator 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63940|63940]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4H4|Q9Y4H4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPSM3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPSM3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618558|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins. {ECO:0000269|PubMed:14656218, ECO:0000269|PubMed:15096500}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GoLoco|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GTPase regulator activity|
|positive regulation of cytokine production involved in inflammatory response|
|regulation of cytokine production involved in inflammatory response|
|positive regulation of leukocyte chemotaxis|
|regulation of leukocyte chemotaxis|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|positive regulation of inflammatory response|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|regulation of inflammatory response|
|positive regulation of cytokine production|
|cellular component|
|positive regulation of defense response|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|positive regulation of response to external stimulus|
|regulation of cytokine production|
|molecular function|
|regulation of defense response|
|regulation of cell migration|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of response to stress|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.74|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.77|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.79|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.88|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|2.01|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.06|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.27|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.3|
|[[:results:exp136|MS094 2μM R03 exp136]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2522
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPSM3 Expression in NALM6 Cells: 4.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>