GRHL3 [The Human Chemical-Genetic Interaction Map Project]

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======= GRHL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRHL3
  * **<color #00a2e8>Official Name</color>**: grainyhead like transcription factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57822|57822]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TE85|Q8TE85]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRHL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRHL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608317|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122). {ECO:0000250|UniProtKB:Q5FWH3, ECO:0000269|PubMed:12549979, ECO:0000269|PubMed:21081122, ECO:0000269|PubMed:24360809, ECO:0000269|PubMed:25347468}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CP2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eyelid development in camera-type eye|
|planar cell polarity pathway involved in neural tube closure|
|regulation of establishment of planar polarity involved in neural tube closure|
|regulation of epithelial tube formation|
|ectoderm development|
|establishment of planar polarity|
|establishment of skin barrier|
|establishment of tissue polarity|
|cochlea morphogenesis|
|regulation of water loss via skin|
|morphogenesis of a polarized epithelium|
|cochlea development|
|multicellular organismal water homeostasis|
|chromatin DNA binding|
|water homeostasis|
|neural tube closure|
|tube closure|
|Wnt signaling pathway, planar cell polarity pathway|
|primary neural tube formation|
|inner ear morphogenesis|
|neural tube formation|
|regulation of establishment of planar polarity|
|ear morphogenesis|
|embryonic epithelial tube formation|
|regulation of embryonic development|
|epithelial tube formation|
|non-canonical Wnt signaling pathway|
|morphogenesis of embryonic epithelium|
|tube formation|
|neural tube development|
|regulation of morphogenesis of an epithelium|
|inner ear development|
|ear development|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|camera-type eye development|
|multicellular organismal homeostasis|
|regulation of actin cytoskeleton organization|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|eye development|
|visual system development|
|sensory system development|
|skin development|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|epidermis development|
|sequence-specific DNA binding|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|wound healing|
|regulation of GTPase activity|
|regulation of body fluid levels|
|regulation of cytoskeleton organization|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|positive regulation of hydrolase activity|
|tube development|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|positive regulation of transcription by RNA polymerase II|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.08|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.7|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8381
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRHL3 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>