GRHPR [The Human Chemical-Genetic Interaction Map Project]

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======= GRHPR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRHPR
  * **<color #00a2e8>Official Name</color>**: glyoxylate and hydroxypyruvate reductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9380|9380]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBQ7|Q9UBQ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRHPR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRHPR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604296|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAD binding 2|
|2-Hacid dh C|
|2-Hacid dh|
|F420 oxidored|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hydroxypyruvate reductase activity|
|glycerate dehydrogenase activity|
|glyoxylate reductase (NADP) activity|
|carboxylic acid binding|
|glyoxylate metabolic process|
|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|
|NADPH binding|
|NAD binding|
|excretion|
|peroxisomal matrix|
|cellular aldehyde metabolic process|
|dicarboxylic acid metabolic process|
|protein complex oligomerization|
|monocarboxylic acid metabolic process|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|protein-containing complex assembly|
|small molecule metabolic process|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.7|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.71|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.85|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6256
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRHPR Expression in NALM6 Cells: 5.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>