GRID2 [The Human Chemical-Genetic Interaction Map Project]

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======= GRID2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRID2
  * **<color #00a2e8>Official Name</color>**: glutamate ionotropic receptor delta type subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2895|2895]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43424|O43424]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRID2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRID2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602368|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine- dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511). {ECO:0000269|PubMed:27418511}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ANF receptor|
|Lig chan-Glu bd|
|SBP bac 3|
|Lig chan|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of long-term synaptic depression|
|cerebellar granular layer formation|
|cerebellar granule cell differentiation|
|ionotropic glutamate receptor activity|
|cerebellar granular layer morphogenesis|
|regulation of postsynaptic density assembly|
|regulation of postsynapse assembly|
|regulation of postsynaptic specialization assembly|
|ionotropic glutamate receptor complex|
|cerebellar granular layer development|
|regulation of long-term synaptic depression|
|excitatory synapse assembly|
|regulation of excitatory synapse assembly|
|prepulse inhibition|
|regulation of postsynaptic density organization|
|glutamate receptor activity|
|parallel fiber to Purkinje cell synapse|
|cell differentiation in hindbrain|
|cerebellar cortex formation|
|ionotropic glutamate receptor signaling pathway|
|startle response|
|synaptic transmission, glutamatergic|
|cerebellar cortex morphogenesis|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|cerebellum morphogenesis|
|hindbrain morphogenesis|
|glutamate receptor signaling pathway|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|cerebellar cortex development|
|integral component of postsynaptic density membrane|
|scaffold protein binding|
|excitatory postsynaptic potential|
|positive regulation of synapse assembly|
|chemical synaptic transmission, postsynaptic|
|PDZ domain binding|
|synapse assembly|
|regulation of postsynapse organization|
|regulation of postsynaptic membrane potential|
|cerebellum development|
|regulation of synapse assembly|
|neuromuscular process|
|metencephalon development|
|dendritic spine|
|hindbrain development|
|central nervous system neuron differentiation|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|regulation of neuron apoptotic process|
|regulation of synapse organization|
|regulation of organelle assembly|
|regulation of synapse structure or activity|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|synapse|
|synapse organization|
|regulation of neuron death|
|glutamatergic synapse|
|negative regulation of response to external stimulus|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|regulation of neuron projection development|
|cell-cell adhesion|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|cell junction|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|brain development|
|head development|
|regulation of neurogenesis|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|central nervous system development|
|neuron differentiation|
|regulation of response to external stimulus|
|cell-cell signaling|
|positive regulation of cellular component organization|
|transmembrane transport|
|regulation of organelle organization|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.85|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.8|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.73|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16039
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRID2 Expression in NALM6 Cells: -4.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>