GRIK2 [The Human Chemical-Genetic Interaction Map Project]

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======= GRIK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRIK2
  * **<color #00a2e8>Official Name</color>**: glutamate ionotropic receptor kainate type subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2898|2898]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13002|Q13002]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRIK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRIK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138244|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lig chan|
|SBP bac 3|
|ANF receptor|
|Lig chan-Glu bd|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extracellularly glutamate-gated ion channel activity|
|ligand-gated ion channel activity involved in regulation of presynaptic membrane potential|
|kainate selective glutamate receptor activity|
|kainate selective glutamate receptor complex|
|regulation of presynaptic membrane potential|
|negative regulation of synaptic transmission, glutamatergic|
|inhibitory postsynaptic potential|
|regulation of short-term neuronal synaptic plasticity|
|glutamate receptor activity|
|ionotropic glutamate receptor signaling pathway|
|regulation of long-term neuronal synaptic plasticity|
|neuronal action potential|
|synaptic transmission, glutamatergic|
|behavioral fear response|
|behavioral defense response|
|dendrite cytoplasm|
|ubiquitin conjugating enzyme binding|
|fear response|
|hippocampal mossy fiber to CA3 synapse|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|neuron apoptotic process|
|glutamate receptor signaling pathway|
|receptor clustering|
|terminal bouton|
|neuron death|
|regulation of neuronal synaptic plasticity|
|positive regulation of neuron apoptotic process|
|transmission of nerve impulse|
|negative regulation of synaptic transmission|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|multicellular organismal response to stress|
|regulation of synaptic transmission, glutamatergic|
|presynaptic membrane|
|localization within membrane|
|PDZ domain binding|
|positive regulation of neuron death|
|action potential|
|regulation of postsynaptic membrane potential|
|perikaryon|
|multicellular organismal signaling|
|negative regulation of neuron apoptotic process|
|positive regulation of synaptic transmission|
|regulation of JNK cascade|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|postsynaptic density|
|ubiquitin protein ligase binding|
|regulation of neuron death|
|glutamatergic synapse|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|protein localization to membrane|
|divalent inorganic cation homeostasis|
|cell junction|
|cellular metal ion homeostasis|
|behavior|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|apoptotic process|
|ion transmembrane transport|
|negative regulation of cell death|
|programmed cell death|
|cell death|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|homeostatic process|
|regulation of cell death|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.77|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16252
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRIK2 Expression in NALM6 Cells: 1.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>