GRIN2B [The Human Chemical-Genetic Interaction Map Project]

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======= GRIN2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRIN2B
  * **<color #00a2e8>Official Name</color>**: glutamate ionotropic receptor NMDA type subunit 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2904|2904]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13224|Q13224]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRIN2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRIN2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138252|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:8768735}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SBP bac 3|
|ANF receptor|
|Lig chan-Glu bd|
|NMDAR2 C|
|Lig chan|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of dendritic spine maintenance|
|glutamate-gated calcium ion channel activity|
|NMDA glutamate receptor activity|
|excitatory chemical synaptic transmission|
|glutamate binding|
|regulation of dendritic spine maintenance|
|NMDA selective glutamate receptor complex|
|glycine binding|
|postsynaptic density membrane|
|negative regulation of synapse organization|
|ionotropic glutamate receptor signaling pathway|
|synaptic membrane|
|protein heterotetramerization|
|regulation of NMDA receptor activity|
|glutamate receptor signaling pathway|
|long-term synaptic potentiation|
|excitatory postsynaptic potential|
|regulation of glutamate receptor signaling pathway|
|calcium ion transmembrane import into cytosol|
|chemical synaptic transmission, postsynaptic|
|calcium ion transport into cytosol|
|regulation of neurotransmitter receptor activity|
|amyloid-beta binding|
|ephrin receptor signaling pathway|
|cytosolic calcium ion transport|
|positive regulation of neuron death|
|regulation of postsynapse organization|
|regulation of postsynaptic membrane potential|
|protein heterooligomerization|
|response to ethanol|
|calcium-mediated signaling|
|protein tetramerization|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of synaptic transmission|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|positive regulation of endopeptidase activity|
|negative regulation of cell projection organization|
|regulation of synaptic plasticity|
|positive regulation of peptidase activity|
|calcium ion transmembrane transport|
|postsynaptic membrane|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|response to alcohol|
|regulation of cysteine-type endopeptidase activity|
|calcium ion transport|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|divalent metal ion transport|
|cognition|
|divalent inorganic cation transport|
|response to antibiotic|
|regulation of neuron death|
|neuron projection|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|positive regulation of proteolysis|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of endopeptidase activity|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|protein complex oligomerization|
|cell junction|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|behavior|
|cation transmembrane transport|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of ion transport|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|regulation of proteolysis|
|brain development|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|head development|
|ion homeostasis|
|cation transport|
|zinc ion binding|
|cellular homeostasis|
|ion transmembrane transport|
|protein phosphorylation|
|central nervous system development|
|response to drug|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|regulation of hydrolase activity|
|phosphorylation|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.86|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.83|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11603
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRIN2B Expression in NALM6 Cells: 0.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>