GRIN3A [The Human Chemical-Genetic Interaction Map Project]

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======= GRIN3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRIN3A
  * **<color #00a2e8>Official Name</color>**: glutamate ionotropic receptor NMDA type subunit 3A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116443|116443]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TCU5|Q8TCU5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRIN3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRIN3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606650|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SBP bac 3|
|Lig chan-Glu bd|
|Lig chan|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NMDA glutamate receptor activity|
|NMDA selective glutamate receptor complex|
|glycine binding|
|prepulse inhibition|
|ionotropic glutamate receptor signaling pathway|
|startle response|
|protein phosphatase 2A binding|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|glutamate receptor signaling pathway|
|calcium channel activity|
|regulation of synaptic vesicle exocytosis|
|regulation of postsynaptic membrane potential|
|dendrite development|
|regulation of neurotransmitter secretion|
|neuromuscular process|
|regulation of synaptic vesicle cycle|
|response to ethanol|
|regulation of neurotransmitter transport|
|regulation of regulated secretory pathway|
|calcium ion transmembrane transport|
|postsynaptic membrane|
|regulation of exocytosis|
|response to alcohol|
|calcium ion transport|
|postsynaptic density|
|synapse|
|divalent metal ion transport|
|divalent inorganic cation transport|
|response to antibiotic|
|neuron projection|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|negative regulation of response to external stimulus|
|neuronal cell body|
|regulation of membrane potential|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|response to toxic substance|
|cell junction|
|regulation of vesicle-mediated transport|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|neuron projection development|
|regulation of secretion by cell|
|regulation of secretion|
|neuron development|
|cation transport|
|regulation of cellular localization|
|ion transmembrane transport|
|neuron differentiation|
|response to drug|
|identical protein binding|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|transmembrane transport|
|ion transport|
|nervous system process|
|generation of neurons|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7349
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRIN3A Expression in NALM6 Cells: 1.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>