GRIP2 [The Human Chemical-Genetic Interaction Map Project]

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======= GRIP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRIP2
  * **<color #00a2e8>Official Name</color>**: glutamate receptor interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80852|80852]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C0E4|Q9C0E4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRIP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRIP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurotransmitter receptor transport, endosome to plasma membrane|
|neurotransmitter receptor transport, endosome to postsynaptic membrane|
|artery smooth muscle contraction|
|endosome to plasma membrane protein transport|
|tonic smooth muscle contraction|
|vascular smooth muscle contraction|
|neurotransmitter receptor transport to plasma membrane|
|neurotransmitter receptor transport to postsynaptic membrane|
|establishment of protein localization to postsynaptic membrane|
|receptor signaling complex adaptor activity|
|retrograde transport, endosome to plasma membrane|
|vasoconstriction|
|neurotransmitter receptor transport|
|protein localization to postsynaptic membrane|
|positive regulation of blood pressure|
|negative regulation of blood vessel diameter|
|receptor localization to synapse|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|smooth muscle contraction|
|establishment of protein localization to plasma membrane|
|protein localization to synapse|
|vesicle-mediated transport to the plasma membrane|
|Notch signaling pathway|
|vesicle-mediated transport in synapse|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|vascular process in circulatory system|
|regulation of blood pressure|
|protein localization to plasma membrane|
|postsynaptic membrane|
|endosomal transport|
|protein localization to cell periphery|
|muscle contraction|
|postsynaptic density|
|protein-containing complex localization|
|establishment of protein localization to membrane|
|muscle system process|
|glutamatergic synapse|
|blood circulation|
|circulatory system process|
|dendrite|
|protein localization to membrane|
|regulation of anatomical structure size|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.99|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9125
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRIP2 Expression in NALM6 Cells: 0.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>