GRSF1 [The Human Chemical-Genetic Interaction Map Project]

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======= GRSF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRSF1
  * **<color #00a2e8>Official Name</color>**: G-rich RNA sequence binding factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2926|2926]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12849|Q12849]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRSF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRSF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604851|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. {ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribonucleoprotein granule|
|mRNA polyadenylation|
|RNA polyadenylation|
|mitochondrial nucleoid|
|mRNA 3-end processing|
|tRNA processing|
|RNA 3-end processing|
|morphogenesis of embryonic epithelium|
|mRNA binding|
|tRNA metabolic process|
|anterior/posterior pattern specification|
|regionalization|
|ncRNA processing|
|morphogenesis of an epithelium|
|pattern specification process|
|ncRNA metabolic process|
|mRNA processing|
|tissue morphogenesis|
|embryonic morphogenesis|
|mRNA metabolic process|
|RNA processing|
|embryo development|
|epithelium development|
|mitochondrion|
|RNA binding|
|RNA metabolic process|
|tissue development|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.03|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.71|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.72|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.74|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.77|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.8|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.81|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.82|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.87|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.91|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.94|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.95|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.95|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.95|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.12|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.16|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.21|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.24|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.34|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.33|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.36|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufb11|NDUFB11]]|0.706|
|[[:human genes:m:mto1|MTO1]]|0.702|
|[[:human genes:a:acad9|ACAD9]]|0.686|
|[[:human genes:n:ndufa1|NDUFA1]]|0.671|
|[[:human genes:n:nubpl|NUBPL]]|0.662|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.655|
|[[:human genes:n:ndufa11|NDUFA11]]|0.654|
|[[:human genes:n:ndufa2|NDUFA2]]|0.649|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.644|
|[[:human genes:n:ndufb10|NDUFB10]]|0.637|
|[[:human genes:n:ndufs2|NDUFS2]]|0.631|
|[[:human genes:n:ndufs8|NDUFS8]]|0.631|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.631|
|[[:human genes:f:fastkd2|FASTKD2]]|0.628|
|[[:human genes:n:ndufb9|NDUFB9]]|0.628|
|[[:human genes:n:ndufb7|NDUFB7]]|0.615|
|[[:human genes:n:ndufa8|NDUFA8]]|0.614|
|[[:human genes:e:ecsit|ECSIT]]|0.612|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.598|
|[[:human genes:n:ndufb6|NDUFB6]]|0.592|
|[[:human genes:c:chchd1|CHCHD1]]|0.585|
|[[:human genes:n:ndufc2|NDUFC2]]|0.584|
|[[:human genes:t:tmem261|TMEM261]]|0.583|
|[[:human genes:n:ndufa3|NDUFA3]]|0.582|
|[[:human genes:n:ndufa10|NDUFA10]]|0.582|
|[[:human genes:n:ndufs5|NDUFS5]]|0.582|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.581|
|[[:human genes:m:mtif2|MTIF2]]|0.58|
|[[:human genes:n:ndufc1|NDUFC1]]|0.575|
|[[:human genes:a:atp5sl|ATP5SL]]|0.565|
|[[:human genes:f:foxred1|FOXRED1]]|0.565|
|[[:human genes:n:ndufb5|NDUFB5]]|0.562|
|[[:human genes:s:ssbp1|SSBP1]]|0.559|
|[[:human genes:n:ndufs3|NDUFS3]]|0.557|
|[[:human genes:n:ndufb4|NDUFB4]]|0.556|
|[[:human genes:n:ndufb2|NDUFB2]]|0.552|
|[[:human genes:r:rpusd3|RPUSD3]]|0.548|
|[[:human genes:m:mrpl45|MRPL45]]|0.547|
|[[:human genes:p:pet117|PET117]]|0.546|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.546|
|[[:human genes:m:mcat|MCAT]]|0.545|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.545|
|[[:human genes:n:ndufs7|NDUFS7]]|0.545|
|[[:human genes:t:tfb1m|TFB1M]]|0.544|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.544|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.541|
|[[:human genes:c:coq7|COQ7]]|0.539|
|[[:human genes:l:lars2|LARS2]]|0.539|
|[[:human genes:q:qrsl1|QRSL1]]|0.536|
|[[:human genes:r:rmnd1|RMND1]]|0.535|
|[[:human genes:p:polg2|POLG2]]|0.535|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.531|
|[[:human genes:m:malsu1|MALSU1]]|0.529|
|[[:human genes:c:c1qbp|C1QBP]]|0.529|
|[[:human genes:f:ftsj2|FTSJ2]]|0.528|
|[[:human genes:s:sfxn4|SFXN4]]|0.528|
|[[:human genes:m:mettl17|METTL17]]|0.524|
|[[:human genes:c:cars2|CARS2]]|0.524|
|[[:human genes:m:mrps21|MRPS21]]|0.523|
|[[:human genes:n:ndufv2|NDUFV2]]|0.522|
|[[:human genes:n:nsun4|NSUN4]]|0.517|
|[[:human genes:n:ndufs1|NDUFS1]]|0.515|
|[[:human genes:p:pet112|PET112]]|0.515|
|[[:human genes:m:mtg1|MTG1]]|0.513|
|[[:human genes:g:gfm1|GFM1]]|0.511|
|[[:human genes:n:nars2|NARS2]]|0.508|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.504|
|[[:human genes:m:mrps18b|MRPS18B]]|0.503|
|[[:human genes:p:prepl|PREPL]]|0.502|
|[[:human genes:m:mrps27|MRPS27]]|0.501|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.499|
|[[:human genes:n:ndufa6|NDUFA6]]|0.498|
|[[:human genes:n:ndufa13|NDUFA13]]|0.496|
|[[:human genes:w:wars2|WARS2]]|0.495|
|[[:human genes:c:c12orf65|C12orf65]]|0.493|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.486|
|[[:human genes:c:c17orf89|C17orf89]]|0.486|
|[[:human genes:n:ndufv1|NDUFV1]]|0.485|
|[[:human genes:c:coq2|COQ2]]|0.484|
|[[:human genes:n:ndufa5|NDUFA5]]|0.483|
|[[:human genes:g:gfm2|GFM2]]|0.483|
|[[:human genes:m:mipep|MIPEP]]|0.483|
|[[:human genes:d:ddx28|DDX28]]|0.479|
|[[:human genes:p:pde12|PDE12]]|0.479|
|[[:human genes:e:eral1|ERAL1]]|0.479|
|[[:human genes:m:mterfd1|MTERFD1]]|0.478|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.477|
|[[:human genes:i:iba57|IBA57]]|0.476|
|[[:human genes:m:mrps5|MRPS5]]|0.475|
|[[:human genes:t:tefm|TEFM]]|0.474|
|[[:human genes:m:mtg2|MTG2]]|0.473|
|[[:human genes:y:yars2|YARS2]]|0.471|
|[[:human genes:m:mrps25|MRPS25]]|0.466|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.465|
|[[:human genes:t:tars2|TARS2]]|0.464|
|[[:human genes:n:ndufa9|NDUFA9]]|0.46|
|[[:human genes:w:wbscr16|WBSCR16]]|0.46|
|[[:human genes:n:ndufb8|NDUFB8]]|0.459|
|[[:human genes:n:ndufb3|NDUFB3]]|0.459|
|[[:human genes:m:mrpl28|MRPL28]]|0.456|
|[[:human genes:p:polg|POLG]]|0.455|
|[[:human genes:m:mrpl43|MRPL43]]|0.452|
|[[:human genes:c:clpp|CLPP]]|0.451|
|[[:human genes:n:noa1|NOA1]]|0.45|
|[[:human genes:m:mrpl47|MRPL47]]|0.446|
|[[:human genes:m:mrpl17|MRPL17]]|0.445|
|[[:human genes:g:glrx5|GLRX5]]|0.444|
|[[:human genes:s:slc25a3|SLC25A3]]|0.443|
|[[:human genes:m:mrpl21|MRPL21]]|0.443|
|[[:human genes:p:polrmt|POLRMT]]|0.442|
|[[:human genes:m:mrpl22|MRPL22]]|0.44|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.44|
|[[:human genes:a:aifm1|AIFM1]]|0.44|
|[[:human genes:p:pnpt1|PNPT1]]|0.44|
|[[:human genes:m:mrpl12|MRPL12]]|0.437|
|[[:human genes:i:ict1|ICT1]]|0.436|
|[[:human genes:r:rars2|RARS2]]|0.434|
|[[:human genes:r:rbfa|RBFA]]|0.433|
|[[:human genes:m:mrps16|MRPS16]]|0.432|
|[[:human genes:m:mdh2|MDH2]]|0.429|
|[[:human genes:m:mrpl53|MRPL53]]|0.428|
|[[:human genes:m:mrpl4|MRPL4]]|0.428|
|[[:human genes:s:selrc1|SELRC1]]|0.427|
|[[:human genes:c:cox18|COX18]]|0.426|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.425|
|[[:human genes:e:ears2|EARS2]]|0.425|
|[[:human genes:a:aars2|AARS2]]|0.424|
|[[:human genes:s:slc25a51|SLC25A51]]|0.423|
|[[:human genes:n:nsun3|NSUN3]]|0.423|
|[[:human genes:p:pars2|PARS2]]|0.422|
|[[:human genes:m:mrp63|MRP63]]|0.421|
|[[:human genes:c:c10orf2|C10orf2]]|0.421|
|[[:human genes:m:mrps12|MRPS12]]|0.418|
|[[:human genes:c:coa3|COA3]]|0.418|
|[[:human genes:m:mrpl15|MRPL15]]|0.418|
|[[:human genes:g:gatc|GATC]]|0.415|
|[[:human genes:c:cluh|CLUH]]|0.415|
|[[:human genes:t:tomm20|TOMM20]]|0.414|
|[[:human genes:p:ptcd3|PTCD3]]|0.412|
|[[:human genes:y:ybey|YBEY]]|0.411|
|[[:human genes:m:mars2|MARS2]]|0.411|
|[[:human genes:m:mrpl3|MRPL3]]|0.411|
|[[:human genes:m:mrpl44|MRPL44]]|0.41|
|[[:human genes:m:mterfd2|MTERFD2]]|0.41|
|[[:human genes:s:sco2|SCO2]]|0.41|
|[[:human genes:r:rpusd4|RPUSD4]]|0.409|
|[[:human genes:p:pdss2|PDSS2]]|0.408|
|[[:human genes:m:mrpl23|MRPL23]]|0.406|
|[[:human genes:m:mrps33|MRPS33]]|0.406|
|[[:human genes:d:dars2|DARS2]]|0.404|
|[[:human genes:v:vars2|VARS2]]|0.403|
|[[:human genes:t:trmt10c|TRMT10C]]|0.402|
|[[:human genes:m:mrps22|MRPS22]]|0.402|
|[[:human genes:t:timm21|TIMM21]]|0.4|
|[[:human genes:m:mrps23|MRPS23]]|0.4|
|[[:human genes:m:mtrf1|MTRF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 33/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|3/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|2/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 919
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRSF1 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>