GSN [The Human Chemical-Genetic Interaction Map Project]

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======= GSN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GSN
  * **<color #00a2e8>Official Name</color>**: gelsolin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2934|2934]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06396|P06396]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GSN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GSN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gelsolin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|renal protein absorption|
|regulation of plasma membrane raft polarization|
|regulation of protein processing in phagocytic vesicle|
|positive regulation of protein processing in phagocytic vesicle|
|positive regulation of keratinocyte apoptotic process|
|actin cap|
|regulation of establishment of T cell polarity|
|regulation of keratinocyte apoptotic process|
|striated muscle atrophy|
|actin filament reorganization|
|muscle atrophy|
|amyloid fibril formation|
|actin filament severing|
|sarcoplasm|
|sequestering of actin monomers|
|myosin II binding|
|response to folic acid|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|hepatocyte apoptotic process|
|regulation of receptor clustering|
|renal absorption|
|regulation of plasma membrane organization|
|barbed-end actin filament capping|
|positive regulation of actin nucleation|
|regulation of podosome assembly|
|regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|negative regulation of viral entry into host cell|
|regulation of establishment of cell polarity|
|positive regulation of protein processing|
|regulation of establishment or maintenance of cell polarity|
|positive regulation of protein maturation|
|regulation of actin nucleation|
|epithelial cell apoptotic process|
|striated muscle adaptation|
|podosome|
|regulation of viral entry into host cell|
|actin filament polymerization|
|myelin sheath|
|actin nucleation|
|muscle adaptation|
|positive regulation of epithelial cell apoptotic process|
|actin filament capping|
|negative regulation of actin filament depolymerization|
|cellular response to cadmium ion|
|oligodendrocyte development|
|protein destabilization|
|actin polymerization or depolymerization|
|regulation of actin filament depolymerization|
|cortical actin cytoskeleton|
|negative regulation of actin filament polymerization|
|phagocytic vesicle|
|negative regulation of protein depolymerization|
|tissue regeneration|
|response to cadmium ion|
|actin cytoskeleton reorganization|
|extracellular matrix disassembly|
|negative regulation of protein polymerization|
|regulation of protein processing|
|regulation of protein maturation|
|oligodendrocyte differentiation|
|negative regulation of protein complex disassembly|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|maintenance of protein location in cell|
|regulation of epithelial cell apoptotic process|
|negative regulation of viral life cycle|
|regulation of protein depolymerization|
|response to vitamin|
|protein polymerization|
|positive regulation of actin filament polymerization|
|ruffle|
|maintenance of location in cell|
|negative regulation of viral process|
|maintenance of protein location|
|glial cell development|
|renal system process|
|regulation of protein complex disassembly|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|response to ethanol|
|positive regulation of protein polymerization|
|phagocytosis, engulfment|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|plasma membrane invagination|
|negative regulation of cytoskeleton organization|
|blood microparticle|
|regulation of viral life cycle|
|membrane invagination|
|positive regulation of cysteine-type endopeptidase activity|
|regeneration|
|cellular response to interferon-gamma|
|maintenance of location|
|regulation of actin filament polymerization|
|glial cell differentiation|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|lamellipodium|
|response to interferon-gamma|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of protein localization to membrane|
|cellular response to metal ion|
|positive regulation of peptidase activity|
|positive regulation of supramolecular fiber organization|
|actin filament binding|
|regulation of viral process|
|gliogenesis|
|response to nutrient|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of multi-organism process|
|actin cytoskeleton|
|positive regulation of cytoskeleton organization|
|regulation of organelle assembly|
|regulation of symbiosis, encompassing mutualism through parasitism|
|cellular response to inorganic substance|
|regulation of protein polymerization|
|response to alcohol|
|actin filament organization|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|actin binding|
|aging|
|regulation of protein stability|
|muscle system process|
|response to antibiotic|
|regulation of T cell activation|
|phagocytosis|
|extracellular matrix organization|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|cilium assembly|
|regulation of supramolecular fiber organization|
|positive regulation of proteolysis|
|cilium organization|
|response to metal ion|
|negative regulation of organelle organization|
|regulation of cellular component size|
|extracellular structure organization|
|developmental growth|
|regulation of actin filament-based process|
|growth|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|focal adhesion|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|wound healing|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|actin cytoskeleton organization|
|response to nutrient levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|response to extracellular stimulus|
|response to inorganic substance|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|endocytosis|
|actin filament-based process|
|response to wounding|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|import into cell|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulated exocytosis|
|negative regulation of cellular component organization|
|calcium ion binding|
|regulation of proteolysis|
|organelle assembly|
|innate immune response|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|exocytosis|
|cellular protein-containing complex assembly|
|membrane organization|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|regulation of cellular component biogenesis|
|central nervous system development|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|cell death|
|response to cytokine|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.17|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.09|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.85|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8925
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GSN Expression in NALM6 Cells: 3.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>