GSR [The Human Chemical-Genetic Interaction Map Project]

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======= GSR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GSR
  * **<color #00a2e8>Official Name</color>**: glutathione-disulfide reductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2936|2936]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00390|P00390]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GSR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GSR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138300|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Maintains high levels of reduced glutathione in the cytosol.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pyr redox|
|Pyr redox 2|
|FAD oxidored|
|Pyr redox dim|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutathione-disulfide reductase activity|
|nucleobase-containing small molecule interconversion|
|NADP binding|
|glutathione metabolic process|
|flavin adenine dinucleotide binding|
|electron transfer activity|
|cell redox homeostasis|
|cellular oxidant detoxification|
|cellular detoxification|
|detoxification|
|electron transport chain|
|cellular modified amino acid metabolic process|
|cellular response to toxic substance|
|cellular response to oxidative stress|
|sulfur compound metabolic process|
|mitochondrial matrix|
|response to oxidative stress|
|external side of plasma membrane|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|response to toxic substance|
|peptide metabolic process|
|nucleobase-containing small molecule metabolic process|
|cellular amide metabolic process|
|cellular homeostasis|
|oxidation-reduction process|
|mitochondrion|
|homeostatic process|
|cellular response to stress|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.83|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.45|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.96|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.87|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.427|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12254
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GSR Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>