GTF2A1 [The Human Chemical-Genetic Interaction Map Project]

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======= GTF2A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF2A1
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIA subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2957|2957]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52655|P52655]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF2A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF2A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333, ECO:0000269|PubMed:16537915}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIIA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription factor TFIIA complex|
|RNA polymerase II general transcription initiation factor activity|
|TBP-class protein binding|
|RNA polymerase II repressing transcription factor binding|
|transcription factor TFIID complex|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|transcription initiation from RNA polymerase II promoter|
|DNA-templated transcription, initiation|
|transcription coactivator activity|
|transcription factor binding|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.73|
|[[:results:exp73|LJH685 5μM R02 exp73]]|1.75|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.79|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.81|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.84|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.88|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.99|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.01|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.17|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.18|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 143/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|1/28|
|blood|3/28|
|bone|3/25|
|breast|8/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/15|
|kidney|14/21|
|liver|7/20|
|lung|9/75|
|lymphocyte|3/14|
|ovary|12/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/7|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1453
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF2A1 Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>