GTF2H3 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= GTF2H3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF2H3
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIH subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2967|2967]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13889|Q13889]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF2H3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF2H3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601750|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre- initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:9852112}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tfb4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|core TFIIH complex portion of holo TFIIH complex|
|phosphorylation of RNA polymerase II C-terminal domain|
|transcriptional preinitiation complex|
|transcription factor TFIIH core complex|
|transcription factor TFIIH holo complex|
|RNA polymerase II general transcription initiation factor activity|
|RNA polymerase II CTD heptapeptide repeat kinase activity|
|nucleotide-excision repair, preincision complex stabilization|
|nucleotide-excision repair, DNA duplex unwinding|
|nucleotide-excision repair, DNA incision, 3-to lesion|
|global genome nucleotide-excision repair|
|transcription elongation from RNA polymerase I promoter|
|nucleotide-excision repair, preincision complex assembly|
|termination of RNA polymerase I transcription|
|7-methylguanosine mRNA capping|
|RNA capping|
|7-methylguanosine RNA capping|
|transcription initiation from RNA polymerase I promoter|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|transcription factor TFIID complex|
|transcription by RNA polymerase I|
|nucleotide-excision repair, DNA incision|
|DNA-dependent ATPase activity|
|DNA-templated transcription, termination|
|transcription-coupled nucleotide-excision repair|
|transcription elongation from RNA polymerase II promoter|
|DNA-templated transcription, elongation|
|protein N-terminus binding|
|nucleotide-excision repair|
|DNA duplex unwinding|
|DNA geometric change|
|transcription initiation from RNA polymerase II promoter|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|protein kinase activity|
|protein-DNA complex subunit organization|
|positive regulation of protein complex assembly|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|regulation of protein complex assembly|
|mRNA processing|
|transcription by RNA polymerase II|
|DNA repair|
|positive regulation of cellular component biogenesis|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|RNA processing|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of cellular component organization|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.05|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.72|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.432|
|[[:human genes:g:gtf2h4|GTF2H4]]|0.428|
|[[:human genes:r:rnmt|RNMT]]|0.415|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.404|
|[[:human genes:o:oraov1|ORAOV1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1119
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF2H3 Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>