GTF3C4 [The Human Chemical-Genetic Interaction Map Project]

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======= GTF3C4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF3C4
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIIC subunit 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9329|9329]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKN8|Q9UKN8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF3C4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF3C4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604892|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-TFIIIC|
|TFIIIC delta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription factor TFIIIC complex|
|5S class rRNA transcription by RNA polymerase III|
|tRNA transcription by RNA polymerase III|
|tRNA transcription|
|transcription initiation from RNA polymerase III promoter|
|rRNA transcription|
|transcription by RNA polymerase III|
|enzyme activator activity|
|histone acetyltransferase activity|
|ncRNA transcription|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein acylation|
|DNA-templated transcription, initiation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|positive regulation of catalytic activity|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.07|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.76|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.96|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg1|ALG1]]|0.636|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.626|
|[[:human genes:t:thg1l|THG1L]]|0.615|
|[[:human genes:t:trmt5|TRMT5]]|0.61|
|[[:human genes:r:rnmt|RNMT]]|0.601|
|[[:human genes:d:dpagt1|DPAGT1]]|0.589|
|[[:human genes:a:atxn10|ATXN10]]|0.583|
|[[:human genes:p:pmm2|PMM2]]|0.581|
|[[:human genes:a:alg5|ALG5]]|0.577|
|[[:human genes:s:srp14|SRP14]]|0.575|
|[[:human genes:r:rtcb|RTCB]]|0.567|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.557|
|[[:human genes:t:tti2|TTI2]]|0.554|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.553|
|[[:human genes:g:gfpt1|GFPT1]]|0.551|
|[[:human genes:g:gmppb|GMPPB]]|0.55|
|[[:human genes:r:rptor|RPTOR]]|0.546|
|[[:human genes:r:rpp21|RPP21]]|0.544|
|[[:human genes:p:polr3h|POLR3H]]|0.543|
|[[:human genes:m:med16|MED16]]|0.542|
|[[:human genes:d:dohh|DOHH]]|0.532|
|[[:human genes:p:pelo|PELO]]|0.529|
|[[:human genes:g:gnb1l|GNB1L]]|0.522|
|[[:human genes:d:dolk|DOLK]]|0.52|
|[[:human genes:e:exoc3|EXOC3]]|0.517|
|[[:human genes:u:uap1|UAP1]]|0.517|
|[[:human genes:a:alg13|ALG13]]|0.514|
|[[:human genes:e:exoc4|EXOC4]]|0.513|
|[[:human genes:a:alg6|ALG6]]|0.511|
|[[:human genes:t:tsen54|TSEN54]]|0.51|
|[[:human genes:c:ccdc101|CCDC101]]|0.505|
|[[:human genes:c:ccdc115|CCDC115]]|0.5|
|[[:human genes:t:triap1|TRIAP1]]|0.498|
|[[:human genes:u:ube2g2|UBE2G2]]|0.498|
|[[:human genes:n:nae1|NAE1]]|0.496|
|[[:human genes:d:dad1|DAD1]]|0.494|
|[[:human genes:t:tti1|TTI1]]|0.494|
|[[:human genes:v:vezt|VEZT]]|0.493|
|[[:human genes:u:uba5|UBA5]]|0.489|
|[[:human genes:s:ssb|SSB]]|0.488|
|[[:human genes:r:rft1|RFT1]]|0.488|
|[[:human genes:d:dhps|DHPS]]|0.483|
|[[:human genes:u:utp23|UTP23]]|0.481|
|[[:human genes:p:ppp4c|PPP4C]]|0.481|
|[[:human genes:s:sec62|SEC62]]|0.48|
|[[:human genes:s:sec63|SEC63]]|0.478|
|[[:human genes:c:cdipt|CDIPT]]|0.478|
|[[:human genes:u:ufsp2|UFSP2]]|0.477|
|[[:human genes:p:ppa2|PPA2]]|0.475|
|[[:human genes:a:alg14|ALG14]]|0.473|
|[[:human genes:p:ppcs|PPCS]]|0.472|
|[[:human genes:t:telo2|TELO2]]|0.471|
|[[:human genes:f:fh|FH]]|0.471|
|[[:human genes:c:cbfb|CBFB]]|0.471|
|[[:human genes:k:kdsr|KDSR]]|0.468|
|[[:human genes:u:uba3|UBA3]]|0.468|
|[[:human genes:m:mbtps2|MBTPS2]]|0.467|
|[[:human genes:u:uhrf1|UHRF1]]|0.465|
|[[:human genes:s:srp72|SRP72]]|0.462|
|[[:human genes:t:tmed10|TMED10]]|0.461|
|[[:human genes:a:alg2|ALG2]]|0.459|
|[[:human genes:t:trnt1|TRNT1]]|0.458|
|[[:human genes:e:elp3|ELP3]]|0.455|
|[[:human genes:m:med23|MED23]]|0.455|
|[[:human genes:o:osgep|OSGEP]]|0.455|
|[[:human genes:a:adsl|ADSL]]|0.454|
|[[:human genes:b:bap1|BAP1]]|0.453|
|[[:human genes:g:gtf3c5|GTF3C5]]|0.453|
|[[:human genes:a:atp5b|ATP5B]]|0.452|
|[[:human genes:r:rpe|RPE]]|0.452|
|[[:human genes:w:wdr24|WDR24]]|0.452|
|[[:human genes:r:romo1|ROMO1]]|0.452|
|[[:human genes:d:dr1|DR1]]|0.45|
|[[:human genes:t:trmt10a|TRMT10A]]|0.45|
|[[:human genes:a:aars|AARS]]|0.45|
|[[:human genes:t:tmem41b|TMEM41B]]|0.45|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.449|
|[[:human genes:f:fen1|FEN1]]|0.449|
|[[:human genes:e:eef1e1|EEF1E1]]|0.448|
|[[:human genes:s:srprb|SRPRB]]|0.447|
|[[:human genes:o:otud5|OTUD5]]|0.447|
|[[:human genes:r:rad1|RAD1]]|0.447|
|[[:human genes:t:ttc4|TTC4]]|0.447|
|[[:human genes:s:srp68|SRP68]]|0.447|
|[[:human genes:p:pdap1|PDAP1]]|0.445|
|[[:human genes:c:cmtr1|CMTR1]]|0.444|
|[[:human genes:r:rabggtb|RABGGTB]]|0.444|
|[[:human genes:v:vmp1|VMP1]]|0.443|
|[[:human genes:d:ddx20|DDX20]]|0.443|
|[[:human genes:b:bub3|BUB3]]|0.441|
|[[:human genes:a:atp5o|ATP5O]]|0.441|
|[[:human genes:d:dhrsx|DHRSX]]|0.44|
|[[:human genes:d:dnajc3|DNAJC3]]|0.438|
|[[:human genes:p:pik3c3|PIK3C3]]|0.437|
|[[:human genes:m:mllt1|MLLT1]]|0.436|
|[[:human genes:a:atp2a2|ATP2A2]]|0.435|
|[[:human genes:x:xpot|XPOT]]|0.432|
|[[:human genes:t:timm22|TIMM22]]|0.432|
|[[:human genes:t:txnl4b|TXNL4B]]|0.431|
|[[:human genes:z:zbtb11|ZBTB11]]|0.431|
|[[:human genes:c:c1orf27|C1orf27]]|0.431|
|[[:human genes:w:wdr59|WDR59]]|0.43|
|[[:human genes:b:brd9|BRD9]]|0.43|
|[[:human genes:o:oraov1|ORAOV1]]|0.429|
|[[:human genes:p:pggt1b|PGGT1B]]|0.428|
|[[:human genes:p:pik3r4|PIK3R4]]|0.428|
|[[:human genes:r:rbm14|RBM14]]|0.427|
|[[:human genes:l:lsm10|LSM10]]|0.427|
|[[:human genes:p:polr3c|POLR3C]]|0.426|
|[[:human genes:g:gemin5|GEMIN5]]|0.426|
|[[:human genes:p:plaa|PLAA]]|0.426|
|[[:human genes:p:polr3b|POLR3B]]|0.426|
|[[:human genes:d:ddost|DDOST]]|0.426|
|[[:human genes:h:haus8|HAUS8]]|0.425|
|[[:human genes:l:lsmd1|LSMD1]]|0.424|
|[[:human genes:l:lsm11|LSM11]]|0.423|
|[[:human genes:c:chchd4|CHCHD4]]|0.423|
|[[:human genes:h:hspd1|HSPD1]]|0.422|
|[[:human genes:t:tbcb|TBCB]]|0.422|
|[[:human genes:e:elac2|ELAC2]]|0.421|
|[[:human genes:s:srd5a3|SRD5A3]]|0.419|
|[[:human genes:e:eny2|ENY2]]|0.419|
|[[:human genes:s:stt3a|STT3A]]|0.418|
|[[:human genes:g:gemin8|GEMIN8]]|0.417|
|[[:human genes:m:mtor|MTOR]]|0.417|
|[[:human genes:p:pam16|PAM16]]|0.415|
|[[:human genes:g:gemin6|GEMIN6]]|0.414|
|[[:human genes:s:slc25a26|SLC25A26]]|0.413|
|[[:human genes:s:sec61g|SEC61G]]|0.413|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.413|
|[[:human genes:a:atp5j|ATP5J]]|0.411|
|[[:human genes:u:ufc1|UFC1]]|0.411|
|[[:human genes:u:uxt|UXT]]|0.41|
|[[:human genes:e:eif4e|EIF4E]]|0.41|
|[[:human genes:w:wdr92|WDR92]]|0.409|
|[[:human genes:g:gtf3a|GTF3A]]|0.409|
|[[:human genes:s:sdha|SDHA]]|0.409|
|[[:human genes:r:rpn1|RPN1]]|0.408|
|[[:human genes:t:ten1|TEN1]]|0.408|
|[[:human genes:u:ube2j1|UBE2J1]]|0.408|
|[[:human genes:t:taz|TAZ]]|0.407|
|[[:human genes:p:ppp6c|PPP6C]]|0.407|
|[[:human genes:m:mbtps1|MBTPS1]]|0.407|
|[[:human genes:d:ddx1|DDX1]]|0.407|
|[[:human genes:t:trim28|TRIM28]]|0.407|
|[[:human genes:t:tbca|TBCA]]|0.406|
|[[:human genes:f:fnta|FNTA]]|0.406|
|[[:human genes:t:taf11|TAF11]]|0.405|
|[[:human genes:m:mapk14|MAPK14]]|0.404|
|[[:human genes:n:nbn|NBN]]|0.404|
|[[:human genes:g:gtf2h3|GTF2H3]]|0.404|
|[[:human genes:a:atrx|ATRX]]|0.404|
|[[:human genes:y:yars|YARS]]|0.404|
|[[:human genes:u:ube2m|UBE2M]]|0.402|
|[[:human genes:c:crcp|CRCP]]|0.401|
|[[:human genes:s:snapc5|SNAPC5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1007
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF3C4 Expression in NALM6 Cells: 6.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>