GTPBP8 [The Human Chemical-Genetic Interaction Map Project]

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======= GTPBP8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTPBP8
  * **<color #00a2e8>Official Name</color>**: GTP binding protein 8 (putative)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29083|29083]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N3Z3|Q8N3Z3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTPBP8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTPBP8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MMR HSR1|
|GTP EFTU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GTP binding|
|mitochondrion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.7|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.76|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.76|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.88|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.92|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.06|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.22|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:malsu1|MALSU1]]|0.542|
|[[:human genes:p:pet112|PET112]]|0.533|
|[[:human genes:n:ndufb10|NDUFB10]]|0.525|
|[[:human genes:a:acad9|ACAD9]]|0.515|
|[[:human genes:f:ftsj2|FTSJ2]]|0.513|
|[[:human genes:n:ndufb11|NDUFB11]]|0.51|
|[[:human genes:n:ndufa2|NDUFA2]]|0.505|
|[[:human genes:m:mtif2|MTIF2]]|0.505|
|[[:human genes:p:pet117|PET117]]|0.504|
|[[:human genes:g:grsf1|GRSF1]]|0.504|
|[[:human genes:n:nsun4|NSUN4]]|0.499|
|[[:human genes:m:mrps21|MRPS21]]|0.498|
|[[:human genes:n:ndufc1|NDUFC1]]|0.497|
|[[:human genes:e:eral1|ERAL1]]|0.494|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.488|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.481|
|[[:human genes:l:lars2|LARS2]]|0.48|
|[[:human genes:c:cars2|CARS2]]|0.477|
|[[:human genes:n:ndufa1|NDUFA1]]|0.477|
|[[:human genes:m:mrpl3|MRPL3]]|0.474|
|[[:human genes:n:nubpl|NUBPL]]|0.474|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.473|
|[[:human genes:p:pde12|PDE12]]|0.473|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.472|
|[[:human genes:m:mto1|MTO1]]|0.472|
|[[:human genes:d:dars2|DARS2]]|0.471|
|[[:human genes:t:tfb1m|TFB1M]]|0.471|
|[[:human genes:m:mrps12|MRPS12]]|0.468|
|[[:human genes:q:qrsl1|QRSL1]]|0.468|
|[[:human genes:p:pars2|PARS2]]|0.467|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.463|
|[[:human genes:m:mrps35|MRPS35]]|0.458|
|[[:human genes:m:mrps16|MRPS16]]|0.456|
|[[:human genes:m:mettl17|METTL17]]|0.456|
|[[:human genes:f:fastkd2|FASTKD2]]|0.456|
|[[:human genes:n:nars2|NARS2]]|0.453|
|[[:human genes:n:ndufb6|NDUFB6]]|0.453|
|[[:human genes:d:ddx28|DDX28]]|0.451|
|[[:human genes:r:rpusd3|RPUSD3]]|0.447|
|[[:human genes:n:ndufa11|NDUFA11]]|0.447|
|[[:human genes:m:mrps26|MRPS26]]|0.446|
|[[:human genes:r:rars2|RARS2]]|0.445|
|[[:human genes:c:cox11|COX11]]|0.445|
|[[:human genes:c:coa3|COA3]]|0.442|
|[[:human genes:n:ndufs2|NDUFS2]]|0.442|
|[[:human genes:n:ndufb4|NDUFB4]]|0.441|
|[[:human genes:p:polrmt|POLRMT]]|0.441|
|[[:human genes:g:gfm1|GFM1]]|0.441|
|[[:human genes:m:mrpl43|MRPL43]]|0.44|
|[[:human genes:m:mrpl21|MRPL21]]|0.439|
|[[:human genes:p:ptcd3|PTCD3]]|0.439|
|[[:human genes:m:mrpl28|MRPL28]]|0.439|
|[[:human genes:e:ears2|EARS2]]|0.439|
|[[:human genes:y:yars2|YARS2]]|0.436|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.433|
|[[:human genes:c:chchd1|CHCHD1]]|0.432|
|[[:human genes:m:mrpl45|MRPL45]]|0.431|
|[[:human genes:m:mrps18b|MRPS18B]]|0.431|
|[[:human genes:n:ndufs5|NDUFS5]]|0.431|
|[[:human genes:n:ndufb9|NDUFB9]]|0.428|
|[[:human genes:s:sfxn4|SFXN4]]|0.428|
|[[:human genes:m:mcat|MCAT]]|0.427|
|[[:human genes:t:tars2|TARS2]]|0.426|
|[[:human genes:m:mars2|MARS2]]|0.424|
|[[:human genes:i:ict1|ICT1]]|0.424|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.423|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.422|
|[[:human genes:m:mrps34|MRPS34]]|0.42|
|[[:human genes:s:ssbp1|SSBP1]]|0.418|
|[[:human genes:m:mrps27|MRPS27]]|0.418|
|[[:human genes:m:mrpl39|MRPL39]]|0.418|
|[[:human genes:n:ndufc2|NDUFC2]]|0.416|
|[[:human genes:m:mrpl37|MRPL37]]|0.416|
|[[:human genes:m:mrpl53|MRPL53]]|0.415|
|[[:human genes:m:mrps25|MRPS25]]|0.415|
|[[:human genes:m:mrpl49|MRPL49]]|0.414|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.413|
|[[:human genes:m:mrps22|MRPS22]]|0.412|
|[[:human genes:t:trub2|TRUB2]]|0.412|
|[[:human genes:m:mtg2|MTG2]]|0.409|
|[[:human genes:v:vars2|VARS2]]|0.409|
|[[:human genes:n:ndufa3|NDUFA3]]|0.408|
|[[:human genes:a:aars2|AARS2]]|0.407|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.407|
|[[:human genes:m:mrpl17|MRPL17]]|0.406|
|[[:human genes:c:coa6|COA6]]|0.406|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.405|
|[[:human genes:t:tmem261|TMEM261]]|0.405|
|[[:human genes:w:wbscr16|WBSCR16]]|0.405|
|[[:human genes:m:mrps7|MRPS7]]|0.404|
|[[:human genes:m:mrpl23|MRPL23]]|0.402|
|[[:human genes:n:ndufv2|NDUFV2]]|0.401|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.401|
|[[:human genes:n:ndufa6|NDUFA6]]|0.401|
|[[:human genes:c:c1qbp|C1QBP]]|0.401|
|[[:human genes:m:mrp63|MRP63]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1043
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTPBP8 Expression in NALM6 Cells: 4.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>