GTSE1 [The Human Chemical-Genetic Interaction Map Project]

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======= GTSE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTSE1
  * **<color #00a2e8>Official Name</color>**: G2 and S-phase expressed 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51512|51512]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYZ3|Q9NYZ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTSE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTSE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607477|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein export from nucleus|
|regulation of protein export from nucleus|
|cytoplasmic microtubule|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|mitotic G1 DNA damage checkpoint|
|positive regulation of nucleocytoplasmic transport|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|positive regulation of protein localization to nucleus|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|regulation of nucleocytoplasmic transport|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|regulation of protein localization to nucleus|
|signal transduction by p53 class mediator|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|positive regulation of intracellular protein transport|
|regulation of cell cycle G1/S phase transition|
|protein stabilization|
|cell cycle checkpoint|
|positive regulation of intracellular transport|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|regulation of intracellular protein transport|
|negative regulation of cell cycle phase transition|
|positive regulation of cell cycle process|
|regulation of protein stability|
|negative regulation of mitotic cell cycle|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|regulation of intracellular transport|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|positive regulation of protein transport|
|regulation of cell cycle phase transition|
|positive regulation of establishment of protein localization|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of locomotion|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|molecular function|
|cellular response to DNA damage stimulus|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|regulation of protein localization|
|regulation of cell cycle|
|cell cycle|
|intracellular signal transduction|
|cellular response to stress|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.07|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-3|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.98|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.86|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.86|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.62|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.59|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.53|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.47|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.45|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.3|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.3|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tacc3|TACC3]]|0.582|
|[[:human genes:d:dlgap5|DLGAP5]]|0.58|
|[[:human genes:g:gak|GAK]]|0.468|
|[[:human genes:a:aspm|ASPM]]|0.452|
|[[:human genes:g:gsg2|GSG2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3877
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTSE1 Expression in NALM6 Cells: 6.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>